%0 Journal Article
%T MODELING STUDY IN THE PARTIAL-FLEXIBLE DOUBLE HELICAL CONFORMATION OF NUCLEIC ACIDS<br>部分柔性的核酸双螺旋构象的模型化研究
%A 李光
%A 温元凯
%J 生物物理学报
%D 1991
%I 
%X From the basic idea of the structural units of nucleic acids, through analyzing and simplifying the freedom set of an arbitrary base-pair-number DNA fragment, the DNA/m5cDNA/RNA double helical models have been built, and the algorithm for partial-flexible two-base-pair model has been created. With this method, the conformational parameters of B-form DNA being; consistent with the experimental data have been given. In terms of the ststistical limitation of DNA intercalating acceptors got from experiments, three-pase-pair DNA acceptors suitable for the intercalators of Adriamycin and its derivatives have been built and refined.
%K 核酸
%K 双螺旋构象
%K 模型化
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=E0C9D9BBED813D6674AC13E942EAC86D&aid=0DD2094E18BBA402BD046DB0A2ADA977&yid=116CB34717B0B183&vid=DF92D298D3FF1E6E&iid=CA4FD0336C81A37A&sid=CA4FD0336C81A37A&eid=E158A972A605785F&journal_id=1000-6737&journal_name=生物物理学报&referenced_num=0&reference_num=1