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PLOS ONE  2012 

New Function for an Old Enzyme: NEP Deficient Mice Develop Late-Onset Obesity

DOI: 10.1371/journal.pone.0012793

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Abstract:

According to the World Health Organization (WHO) there is a pandemic of obesity with approximately 300 million people being obese. Typically, human obesity has a polygenetic causation. Neutral endopeptidase (NEP), also known as neprilysin, is considered to be one of the key enzymes in the metabolism of many active peptide hormones.

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