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生物物理学报 2004
Discovery of a cellular pathway on energy-consuming protein degradation --Introducing the work that was awarded the Nobel Prize in Chemistry for 2004.
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Abstract:
The Nobel Prize in Chemistry for 2004 was awarded to Aaron Ciechanover, Avram Hershko and Irwin Rose, for their discovery of the ubiquitin-mediated protein degradation (proteolysis). Their discoveries are reviewed here in a historical perspective. Lessons that might be learned from their experiences are discussed.