MODEL ANALYSIS OF GRADED DENDRITIC SPIKESIN HIPPOCAMPAL CA1 PYRAMIDAL CELLS
海马CA1区锥体细胞树突分级峰电位的模型分析

Neurons in the brain are endowed with complex information processing functions by their complex dendritic tree structures and voltage-gated ion channels. The neuronal information integration properties were investigated by means of branch morphological model and voltage-gated ion channel kinetic models, including the transient K channel. The results show that the voltage level of distal dendritic spikes is graded in a large range of input intensity, the initiation site of action potential can shift along the apical dendrite, and the amplitude of the back-propagating spike can decrease abruptly when it reaches the distal dendrite.