Study on Law of Protein-protein Interactions Based on Structural Information
基于结构信息的蛋白质相互作用规律的研究

Protein-protein interaction is one of the important ways that proteins fulfill their roles. Defining parameter describing protein-protein interaction relative bias, the law of protein interaction between or within organelles, membranes for S. cerevisiae's, different classes for S. cerevisiae's, C. elegans and E. coli were investigated based on the databast of interacting protein(DIP), gene ontology(GO), structural classification of proteins(SCOP) and related databases such as SWISS-PROT in this work. The results indicated that there exists obvious bias of protein-protein interaction between or within different organelles, membranes and classes. The biological implication was discussed briefly.