AN APPROACH TO DESIGN PROTEINS OF FOUR STRUCTURAL CLASSES
四种结构类型的蛋白质设计方法

A design method for identifying the correct hydrophobic or polar class of residues was presented in previous work. This approach is based entirely on the physical principle and the relative entropy is used as a minimization object function. The algorithm is used to perform the design on target conformations corresponding to the native states of four structural classes of real proteins. The failure to increase the design success score are also analyzed and discussed. The method is general and can be extended to design proteins of different structural classes.