%0 Journal Article
%T AN APPROACH TO DESIGN PROTEINS OF FOUR STRUCTURAL CLASSES<br>四种结构类型的蛋白质设计方法
%A LIU Yun
%A WANG Yi-hua
%A WANG Bao-han
%A WANG Cun-xin
%A CHEN Wei-zu
%A <br>刘赟
%A 王屹华
%A 王宝翰
%A 王存新
%A 陈慰祖
%J 生物物理学报
%D 2004
%I 
%X A design method for identifying the correct hydrophobic or polar class of residues was presented in previous work. This approach is based entirely on the physical principle and the relative entropy is used as a minimization object function. The algorithm is used to perform the design on target conformations corresponding to the native states of four structural classes of real proteins. The failure to increase the design success score are also analyzed and discussed. The method is general and can be extended to design proteins of different structural classes.
%K Protein design
%K Inverse protein folding
%K Structural classes
%K Off-lattice model<br>蛋白质设计
%K 蛋白质逆折叠
%K 结构类型
%K 非格子模型
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=E0C9D9BBED813D6674AC13E942EAC86D&aid=F66DA0E1C1E4097F&yid=D0E58B75BFD8E51C&vid=A04140E723CB732E&iid=E158A972A605785F&sid=F416A9924F23B020&eid=AA5FB09E1F81059E&journal_id=1000-6737&journal_name=生物物理学报&referenced_num=0&reference_num=14