INDUCTION OF EXPRESSION OF PROTO-ONCOGENE C FOS AND ORNITHINE DECARBOXYLASE GENES BY TRANSIENT CEREBRAL ISCHEMIA
暂时性脑缺血诱导c-fos原癌基因和鸟氨酸脱羧酶基因表达

The levels of mRNAs for proto-oncogene c-fos and ornithine decarboxylase (ODC)genes were measured in rat cerebral cortex and hippocampus at various recirculation intervals after 20 minutes of ischemia. Striking increases in c-fos and ODC genes expression were observed in rat cerebral cortex 0.5-3h and 6-14h respectively after recirculation. In the meantime, delayed expression of of c-fos and ODC genes were noticed in rat hippocampus 36~72h after recirculation. In contrast to c-fos and ODC genes, c-myc gene expression can not be induced by ischemia. These results imply some specific role of c-fos and ODC after ischemic brain injury. In this article, we analysed the mechanism that recirculation after ischemia induces c-fos and ODC genes expression, and proposed the concept - neuronal stress state to describe neuronal response to destructive stimulation.