%0 Journal Article
%T INDUCTION OF EXPRESSION OF PROTO-ONCOGENE C FOS AND ORNITHINE DECARBOXYLASE GENES BY TRANSIENT CEREBRAL ISCHEMIA<br>暂时性脑缺血诱导c-fos原癌基因和鸟氨酸脱羧酶基因表达
%A 许开明
%A 范子体
%A 范慕贞
%A 刘划
%A 陈惟昌
%J 生物物理学报
%D 1992
%I 
%X The levels of mRNAs for proto-oncogene c-fos and ornithine decarboxylase (ODC)genes were measured in rat cerebral cortex and hippocampus at various recirculation intervals after 20 minutes of ischemia. Striking increases in c-fos and ODC genes expression were observed in rat cerebral cortex 0.5-3h and 6-14h respectively after recirculation. In the meantime, delayed expression of of c-fos and ODC genes were noticed in rat hippocampus 36~72h after recirculation. In contrast to c-fos and ODC genes, c-myc gene expression can not be induced by ischemia. These results imply some specific role of c-fos and ODC after ischemic brain injury. In this article, we analysed the mechanism that recirculation after ischemia induces c-fos and ODC genes expression, and proposed the concept - neuronal stress state to describe neuronal response to destructive stimulation.
%K Recirculation After Ischemia C-fos Gene ODC Gene Hippocampus Neuronal Stress State<br>ODC基因
%K 脑缺血
%K 原癌基因
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=E0C9D9BBED813D6674AC13E942EAC86D&aid=6F4B2AF07746A9C4FDE3955E3F78133E&yid=F53A2717BDB04D52&vid=5D311CA918CA9A03&iid=E158A972A605785F&sid=5A027C8E6C570AAB&eid=569BDAA4FEA0F7F9&journal_id=1000-6737&journal_name=生物物理学报&referenced_num=0&reference_num=1