Bioavailability and Pharmacokinetics of Ibafloxacin Following Intravenous and Intramuscular Single-Dose Applications in Chickens

The single-dose pharmacokinetics of ibafloxacin was studied in clinically normal chickens after intravenous and intramuscular administration of 7.5 mg of ibafloxacin kg￣1 of body weight. Ibafloxacin concentrations were determined by Microbiological assay method. The distribution and elimination half-lives were 0.261 and 5.87 h, respectively. Steady-state volume of distribution and clearance of ibafloxacin after intravenous administration were 4.09 L kg￣1 and 0.519 L kg￣1 h￣1, respectively. Following intramuscular administration, ibafloxacin achieved maximum plasma concentration of 1.06 μg mL￣1 achieved after maximum time of 1.3 h post-injection. The systemic bioavailability after intramuscular injection was 79.6% and the extent of serum protein binding was 27.04%. Ibafloxacin could be useful in the treatment of systemic infections in chickens after specific assessment of susceptible microorganisms.