%0 Journal Article %T Bioavailability and Pharmacokinetics of Ibafloxacin Following Intravenous and Intramuscular Single-Dose Applications in Chickens %A M.A. Tohamy %J Research Journal of Pharmacology %D 2013 %I %R 10.3923/rjpharm.2011.22.26 %X The single-dose pharmacokinetics of ibafloxacin was studied in clinically normal chickens after intravenous and intramuscular administration of 7.5 mg of ibafloxacin kg£þ1 of body weight. Ibafloxacin concentrations were determined by Microbiological assay method. The distribution and elimination half-lives were 0.261 and 5.87 h, respectively. Steady-state volume of distribution and clearance of ibafloxacin after intravenous administration were 4.09 L kg£þ1 and 0.519 L kg£þ1 h£þ1, respectively. Following intramuscular administration, ibafloxacin achieved maximum plasma concentration of 1.06 ¦Ìg mL£þ1 achieved after maximum time of 1.3 h post-injection. The systemic bioavailability after intramuscular injection was 79.6% and the extent of serum protein binding was 27.04%. Ibafloxacin could be useful in the treatment of systemic infections in chickens after specific assessment of susceptible microorganisms. %U http://www.medwellonline.net/abstract/?doi=rjpharm.2011.22.26