Emerging treatment approaches in acute lymphoblastic and acute myeloid leukemias

ging treatment approaches in acute lymphoblastic and acute myeloid leukemias Review (1767) Total Article Views Authors: Thomas X Published Date March 2012 Volume 2012:2 Pages 57 - 76 DOI: http://dx.doi.org/10.2147/BLCTT.S15567 Received: 16 November 2011 Accepted: 17 January 2012 Published: 08 March 2012 Xavier Thomas Hospices Civils de Lyon, Centre Hospitalier Lyon-Sud, Service d'Hématologie Clinique, Pavillon Marcel Bérard, Bat.1G, Pierre Bénite, France Abstract: The choice of treatment approach in acute leukemia depends on well-established prognostic factors. A number of features can predict the outcome of treatment including cytogenetics and an increasing list of molecular features. These are increasingly being used to direct postinduction therapy and support risk-adapted treatments that should achieve optimal results while minimizing nonrelapse mortality. In addition, they are also molecular targets for a new generation of small molecule inhibitors that are in early development and promise to further improve outcomes in the coming decade.