Significant pain relief with loading dose zoledronic acid in bone metastases is only seen in patients with elevated initial serum C telopeptide (CTX)

nificant pain relief with loading dose zoledronic acid in bone metastases is only seen in patients with elevated initial serum C telopeptide (CTX) Original Research (1685) Total Article Views Authors: Dekoninck J, Geurs F, De Loecker R, Deprest Y Published Date July 2011 Volume 2011:2 Pages 13 - 18 DOI: http://dx.doi.org/10.2147/POR.S15391 J Dekoninck1, F Geurs1, R De Loecker2, Y Deprest2 1Department of Medical Oncology, 2Laboratory, Regional Hospital Sint Maria, Halle, Belgium Abstract: In symptomatic bone metastases with significant pain, refractory to standard analgesics and radiotherapy, loading dose zoledronic acid (ZA) represents a simple and nontoxic treatment to obtain significant pain relief in a very short time. Its analgesic effect is limited to patients with massive osteoclast activation with high initial serum C-telopeptide (CTX). The pain reduction is proportionally correlated with the reduction of CTX.