%0 Journal Article %T Significant pain relief with loading dose zoledronic acid in bone metastases is only seen in patients with elevated initial serum C telopeptide (CTX) %A Dekoninck J %A Geurs F %A De Loecker R %A Deprest Y %J Pragmatic and Observational Research %D 2011 %I Dove Medical Press %R http://dx.doi.org/10.2147/POR.S15391 %X nificant pain relief with loading dose zoledronic acid in bone metastases is only seen in patients with elevated initial serum C telopeptide (CTX) Original Research (1685) Total Article Views Authors: Dekoninck J, Geurs F, De Loecker R, Deprest Y Published Date July 2011 Volume 2011:2 Pages 13 - 18 DOI: http://dx.doi.org/10.2147/POR.S15391 J Dekoninck1, F Geurs1, R De Loecker2, Y Deprest2 1Department of Medical Oncology, 2Laboratory, Regional Hospital Sint Maria, Halle, Belgium Abstract: In symptomatic bone metastases with significant pain, refractory to standard analgesics and radiotherapy, loading dose zoledronic acid (ZA) represents a simple and nontoxic treatment to obtain significant pain relief in a very short time. Its analgesic effect is limited to patients with massive osteoclast activation with high initial serum C-telopeptide (CTX). The pain reduction is proportionally correlated with the reduction of CTX. %K bone resorption %K bisphosphonates %K CTX levels %K VAS score %U https://www.dovepress.com/significant-pain-relief-with-loading-dose-zoledronic-acid-in-bone-meta-peer-reviewed-article-POR