Metabolic syndrome and its components associated with endothelial dysfunction in chronic kidney disease patients

abolic syndrome and its components associated with endothelial dysfunction in chronic kidney disease patients Original Research (2920) Total Article Views Authors: Bai Q, Lai X, Zhang AH, Lu XH, Tian SL, Fan MH, Wang Y, Wang T Published Date January 2012 Volume 2012:8 Pages 15 - 21 DOI: http://dx.doi.org/10.2147/VHRM.S27444 Received: 18 October 2011 Accepted: 11 November 2011 Published: 06 January 2012 Qiong Bai, Xuan Lai, Ai-Hua Zhang, Xin-Hong Lu, Shun-Li Tian, Min-Hua Fan, Yue Wang, Tao Wang Division of Nephrology, Peking University Third Hospital, Beijing, People's Republic of China Background: Cardiovascular disease is more common in patients with chronic kidney disease (CKD) than in the general population. Endothelial dysfunction is an early predictor of cardiovascular events. Objective: We conducted a cross-sectional study in CKD patients to explore the association of metabolic syndrome (MetS) components with endothelial cell function. Methods: We evaluated clinical and laboratory data in 161 CKD patients from stage 1 to stage 5. Endothelial function was estimated by flow-mediated dilatation (FMD) of the brachial artery and expressed as percentage change relative to baseline diameter. MetS was defined according to the National Cholesterol Education Program-Adult Treatment Panel III criteria. Results: Patients were grouped into two groups according to whether or not they had MetS. FMD was significantly lower in the MetS group than in the group without MetS (P = 0.012). In a Pearson's correlation analysis, FMD was significantly negatively correlated with waist circumference in women (r = –0.223, P = 0.03) and fasting blood glucose (r = –0.186, P = 0.001). Multiple linear regression analysis showed that fasting blood glucose was an independently associated factor for FMD. Conclusion: MetS and some components of MetS (waist circumference in women and fasting blood glucose) are closely associated with a decreased FMD in CKD patients.