%0 Journal Article
%T Metabolic syndrome and its components associated with endothelial dysfunction in chronic kidney disease patients
%A Bai Q
%A Lai X
%A Zhang AH
%A Lu XH
%A Tian SL
%A Fan MH
%A Wang Y
%A Wang T
%J Vascular Health and Risk Management
%D 2012
%I 
%R http://dx.doi.org/10.2147/VHRM.S27444
%X abolic syndrome and its components associated with endothelial dysfunction in chronic kidney disease patients Original Research (2920) Total Article Views Authors: Bai Q, Lai X, Zhang AH, Lu XH, Tian SL, Fan MH, Wang Y, Wang T Published Date January 2012 Volume 2012:8 Pages 15 - 21 DOI: http://dx.doi.org/10.2147/VHRM.S27444 Received: 18 October 2011 Accepted: 11 November 2011 Published: 06 January 2012 Qiong Bai, Xuan Lai, Ai-Hua Zhang, Xin-Hong Lu, Shun-Li Tian, Min-Hua Fan, Yue Wang, Tao Wang Division of Nephrology, Peking University Third Hospital, Beijing, People's Republic of China Background: Cardiovascular disease is more common in patients with chronic kidney disease (CKD) than in the general population. Endothelial dysfunction is an early predictor of cardiovascular events. Objective: We conducted a cross-sectional study in CKD patients to explore the association of metabolic syndrome (MetS) components with endothelial cell function. Methods: We evaluated clinical and laboratory data in 161 CKD patients from stage 1 to stage 5. Endothelial function was estimated by flow-mediated dilatation (FMD) of the brachial artery and expressed as percentage change relative to baseline diameter. MetS was defined according to the National Cholesterol Education Program-Adult Treatment Panel III criteria. Results: Patients were grouped into two groups according to whether or not they had MetS. FMD was significantly lower in the MetS group than in the group without MetS (P = 0.012). In a Pearson's correlation analysis, FMD was significantly negatively correlated with waist circumference in women (r = ¨C0.223, P = 0.03) and fasting blood glucose (r = ¨C0.186, P = 0.001). Multiple linear regression analysis showed that fasting blood glucose was an independently associated factor for FMD. Conclusion: MetS and some components of MetS (waist circumference in women and fasting blood glucose) are closely associated with a decreased FMD in CKD patients.
%K metabolic syndrome
%K endothelial dysfunction
%K flow-mediated dilatation
%K chronic kidney disease
%U https://www.dovepress.com/metabolic-syndrome-and-its-components-associated-with-endothelial-dysf-peer-reviewed-article-VHRM