New form of administering chlorhexidine for treatment of denture-induced stomatitis

rm of administering chlorhexidine for treatment of denture-induced stomatitis Original Research (2913) Total Article Views Authors: Ryalat S, Darwish R, Amin W Published Date June 2011 Volume 2011:7 Pages 219 - 225 DOI: http://dx.doi.org/10.2147/TCRM.S18297 Soukaina Ryalat, Rula Darwish, Wala Amin Department of Oral Surgery, Jordan University, Amman, Jordan Background: The purpose of this study was to evaluate the release of chlorhexidine as an antifungal drug from doped self-cured poly (methyl methacrylate) (PMMA) acrylic resin and the effect of the drug released on the growth of Candida albicans. Methods: Release of chlorhexidine was evaluated using liquid chromatography, and the effect of the drug on the growth of C. albicans was investigated microbiologically using a “well” technique on Saboraud culture medium inoculated with a resistant strain of C. albicans. Results: Chlorhexidine leached steadily out of the acrylic resin into distilled water at mouth temperature, and the sustained drug release continued throughout the 28-day test period. The drug released also demonstrated antifungal activity against the resistant strain of C. albicans. Conclusion: The findings of this study support the use of chlorhexidine-impregnated self-cured PMMA chair-side resin as a new dosage form for the treatment of denture-induced stomatitis.