%0 Journal Article
%T New form of administering chlorhexidine for treatment of denture-induced stomatitis
%A Ryalat S
%A Darwish R
%A Amin W
%J Therapeutics and Clinical Risk Management
%D 2011
%I 
%R http://dx.doi.org/10.2147/TCRM.S18297
%X rm of administering chlorhexidine for treatment of denture-induced stomatitis Original Research (2913) Total Article Views Authors: Ryalat S, Darwish R, Amin W Published Date June 2011 Volume 2011:7 Pages 219 - 225 DOI: http://dx.doi.org/10.2147/TCRM.S18297 Soukaina Ryalat, Rula Darwish, Wala Amin Department of Oral Surgery, Jordan University, Amman, Jordan Background: The purpose of this study was to evaluate the release of chlorhexidine as an antifungal drug from doped self-cured poly (methyl methacrylate) (PMMA) acrylic resin and the effect of the drug released on the growth of Candida albicans. Methods: Release of chlorhexidine was evaluated using liquid chromatography, and the effect of the drug on the growth of C. albicans was investigated microbiologically using a ˇ°wellˇ± technique on Saboraud culture medium inoculated with a resistant strain of C. albicans. Results: Chlorhexidine leached steadily out of the acrylic resin into distilled water at mouth temperature, and the sustained drug release continued throughout the 28-day test period. The drug released also demonstrated antifungal activity against the resistant strain of C. albicans. Conclusion: The findings of this study support the use of chlorhexidine-impregnated self-cured PMMA chair-side resin as a new dosage form for the treatment of denture-induced stomatitis.
%K chlorhexidine
%K poly (methyl methacrylate)
%K eluates
%K antifungal drug
%K denture stomatitis
%K Candida albicans
%U https://www.dovepress.com/new-form-of-administering-chlorhexidine-for-treatment-of-denture-induc-peer-reviewed-article-TCRM