Alteraciones hemostáticas en pacientes con sangrado uterino anormal

objective: to know the frequency of hemostatic defects in women with abnormal uterine bleeding methods: 55 patients, 17 to 55 years of age, with abnormal uterine bleeding, were studied. a clinical history, a physical examination that included a gynecological exam, endometrial biopsy, and pelvic and transvaginal echograms, comprised the evaluation in each patient. a haemostatic profile was also performed that included: prothrombin and partial thromboplastin times, factors viii (fviii), von willebrand (vwf) and ix (fiv) determinations, and platelet aggregation with epinephrine, adp, collagen and ristocetin. setting: nuestra se？ora de chiquinquira hospital, maracaibo. venezuela and instituto de investigaciones clinicas " dr. americo negrette", facultad de medicina. universidad del zulia. results: all women had either an organic, functional or mixed genital alteration. coagulation times and concentration of factors were normal, with the exception of one patient with 0.47u/μl of fviii. in 51.1 % of the cases, the platelet aggregation was defective. conclusion: the frequency of coagulation defects was similar in patients with abnormal uterine bleeding and the general population. for this reason, a thorough coagulation profile is not justified in all patients with abnormal uterine bleeding, however, the high proportion of abnormal platelet aggregations should be taken into account before a surgical procedure.