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Polimorfismo rs3091244 del gen de la proteína C reactiva influencia los niveles séricos de CRP-hs en individuos de la región de La Araucanía

DOI: 10.4067/S0718-85602011000100003

Keywords: hs-crp, crp gene, risk factors.

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Abstract:

background: several genes and their polymorphisms have been associated with atherosclerotic plaque formation and subsequent development of cardiovascular disease. one of them is the c-reactive protein (crp) encoding gene, crp being a recognized important pro-inflammatory and inflammatory marker. biallelics and triallelics single nucleotide polymorphisms (snps) in the promoter region of this gene have been identified. the rs3040244 c>t>a is known as the variant most strongly associated with high hs-crp levels. however, the results between populations are contradictory. thus, the purpose of this study was to investigate the possible association between the rs3091244 polymorphism and serum levels of hs-crp in southern chilean individuals. methods: we determined the serum hs-crp in 157 unrelated adult subjects. the rs3091244 polymorphism was detected by pcr-rflp. results: the genotype distribution for the rs3091244 polymorphism of the crp gene was as follows: cc 11.5%, ct 45.2%, tt 31.2%, ca 5.0% and ta 7.0%. individuals carrying the tt and ta genotypes showed higher serum hs-crp when compared to the reference cc genotype (p = 0.030 and p = 0.002, respectively). conclusion: our data shows that the rs3091244 snp of the crp gene contributes to increase the hs-crp levels, which may imply an increased cardiovascular risk.

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