%0 Journal Article
%T Polimorfismo rs3091244 del gen de la prote¨ªna C reactiva influencia los niveles s¨¦ricos de CRP-hs en individuos de la regi¨®n de La Araucan¨ªa
%A Saavedra
%A Nicol¨¢s
%A Fallard
%A Angela
%A Araya
%A Marco
%A Ser¨®n
%A Pamela
%A Lanas
%A Fernando
%A Salazar
%A Luis A
%J Revista chilena de cardiolog¨ªa
%D 2011
%I Scientific Electronic Library Online
%R 10.4067/S0718-85602011000100003
%X background: several genes and their polymorphisms have been associated with atherosclerotic plaque formation and subsequent development of cardiovascular disease. one of them is the c-reactive protein (crp) encoding gene, crp being a recognized important pro-inflammatory and inflammatory marker. biallelics and triallelics single nucleotide polymorphisms (snps) in the promoter region of this gene have been identified. the rs3040244 c>t>a is known as the variant most strongly associated with high hs-crp levels. however, the results between populations are contradictory. thus, the purpose of this study was to investigate the possible association between the rs3091244 polymorphism and serum levels of hs-crp in southern chilean individuals. methods: we determined the serum hs-crp in 157 unrelated adult subjects. the rs3091244 polymorphism was detected by pcr-rflp. results: the genotype distribution for the rs3091244 polymorphism of the crp gene was as follows: cc 11.5%, ct 45.2%, tt 31.2%, ca 5.0% and ta 7.0%. individuals carrying the tt and ta genotypes showed higher serum hs-crp when compared to the reference cc genotype (p = 0.030 and p = 0.002, respectively). conclusion: our data shows that the rs3091244 snp of the crp gene contributes to increase the hs-crp levels, which may imply an increased cardiovascular risk.
%K hs-crp
%K crp gene
%K risk factors.
%U http://www.scielo.cl/scielo.php?script=sci_abstract&pid=S0718-85602011000100003&lng=en&nrm=iso&tlng=en