Detección precoz por Tomografía Computada Cuantitativa Multicorte de alteraciones en la densidad mineral ósea, inducidas por una dieta aterogénica, en un modelo experimental en ratas en crecimiento

purpose. to demónstrate the utility of multislice quantitative computed tomography (ms-qct) in the early detection of mandibular bone mineral density (bmd) alterations induced by an atherogenic diet in a growing rat experimental model. materials and methods. male weanling wistar rats (n =16) were divided by body weight (wt) into 2 groups: control (c) and experimental (e), with no significant differences in the mean initial wt (p>0.05). c was fed rodent stock diet ad libitum, and e an atherogenic diet for 3 weeks (3w). zoometry (body weight and length) and diet intake (g/loog rat/day) were monitored. at 3 w in serum (mg/dl) lipid-lipoprotein profile was studied: total cholesterol (t-c), triglycerides (tg), high-density lipoprotein cholesterol (hdl-c), non-hdl cholesterol (non-hdl-c) and ms-qct (philips 64 ct, quantified with the efilm workstation 2.1) in seven mandibular áreas (ma): n°lto 4: from chin to mandibular foramen, n° 5: coronoid process, n° 6: condylar process, n° 7: angular process. statistics: pearson's correlation between bmd in each ma and serum t-c. p<0.05 was considered significant. results. (mean ± sd) at 3w, neither zoometric ？or intake differences were observed (p>0.05). correlation coefficients (r) and their significance levéis (p) were relevant in 5/7 ma. ma1-.-0.580 (p=0.019), ma2:-0.709 (p=0.002), ma3:-0.635 (p=0.008), ma5:-0.674 (p=0.004), ma6:-0.564 (p=0.023). conclusions. these results suggest that ms-qct is an imaging diagnostic method that allows the early detection of mandible bone architecture alterations induced by an atherogenic diet. inverse correlation between bmd and t-c would indícate an association between an atherogenic diet intake and potential temporomandibular disorders.