Densidad mineral ósea en pacientes premenopáusicas con depresión: Relación con los niveles séricos de cortisol, proteina c reactiva y marcadores óseos

objective: to evaluate bmd in premenopausal women with and without depression and its relationship to serum cortisol, c-reactive protein (crp) and bone markers. methods: an observational study, cross-sectional, analytical, case-control sub-model, was conducted. the study included 40 premenopausal women (between 30 and 45 years), 20 with depression, using the criteria of the 17-item hamilton rating scale for depression (ham-d), and 20 healthy controls. cortisol, us-crp and bone markers (osteocalcin and β cross laps) serum levels were quantified. spine and hip bmd, using lunar dxa machine, was performed. results: the mean age was 39,40 ± 4,79 years for cases and 39,20 ± 5,63 for controls; bmi 27,36 kg/m2 for both groups. there were not significant differences in clinical characteristics. bmd of the spine and hip were significantly lower in depressed than in nondepressed women (1,132 ± 0,10 vs 1,215 ± 0,14 p <0,045 and 0,991±0,13 vs 1,090 p<0,012 respectively). it made the crossing of the hamilton test results with bone markers, cortisol, us-crp, and spine and hip bmd; there was a lower hip bmd in patients with depression (p = 0,002). there were not differences in biochemical variables. conclusion: our findings suggest that depression is a significant risk factor for low bone mass in premenopausal women. therefore, periodic evaluations of bmd and prophylactic measures should be promoted in monitoring of these patients.