%0 Journal Article
%T Densidad mineral 車sea en pacientes premenop芍usicas con depresi車n: Relaci車n con los niveles s谷ricos de cortisol, proteina c reactiva y marcadores 車seos
%A Guerrero U
%A Yorly J
%A Uzc芍tegui
%A Lilia R
%A Torres
%A Adri芍n
%A Escalante
%A Karen
%A Acosta
%A Marta
%J Revista Venezolana de Endocrinolog赤a y Metabolismo
%D 2010
%I Sociedad Venezolana de Endocrinolog赤a y Metabolismo
%X objective: to evaluate bmd in premenopausal women with and without depression and its relationship to serum cortisol, c-reactive protein (crp) and bone markers. methods: an observational study, cross-sectional, analytical, case-control sub-model, was conducted. the study included 40 premenopausal women (between 30 and 45 years), 20 with depression, using the criteria of the 17-item hamilton rating scale for depression (ham-d), and 20 healthy controls. cortisol, us-crp and bone markers (osteocalcin and 汕 cross laps) serum levels were quantified. spine and hip bmd, using lunar dxa machine, was performed. results: the mean age was 39,40 ㊣ 4,79 years for cases and 39,20 ㊣ 5,63 for controls; bmi 27,36 kg/m2 for both groups. there were not significant differences in clinical characteristics. bmd of the spine and hip were significantly lower in depressed than in nondepressed women (1,132 ㊣ 0,10 vs 1,215 ㊣ 0,14 p <0,045 and 0,991㊣0,13 vs 1,090 p<0,012 respectively). it made the crossing of the hamilton test results with bone markers, cortisol, us-crp, and spine and hip bmd; there was a lower hip bmd in patients with depression (p = 0,002). there were not differences in biochemical variables. conclusion: our findings suggest that depression is a significant risk factor for low bone mass in premenopausal women. therefore, periodic evaluations of bmd and prophylactic measures should be promoted in monitoring of these patients.
%K osteoporosis
%K depresi車n
%K densidad mineral 車sea
%K cortisol
%K pcr.
%U http://www.scielo.org.ve/scielo.php?script=sci_abstract&pid=S1690-31102010000300002&lng=en&nrm=iso&tlng=en