Efecto diurético de extractos acuosos y alcohólicos de flores de Phrygilanthus acutifolius (corpo) en ratas

an experimental study was conducted in wistar rats, to evaluate the potential diuretic effect of aqueous and ethanol extracts of flowers from phrygilanthus acutifolius (ruiz & pav.) eichler in doses of 200 and 400 mg/kg of body weight. results were compared to those obtained from furosemide in dose of 20 mg/kg of body weight (reference diuretic) and saline solution (negative control). urinary excretion was measured at 24 h, and the concentration of na+ , k+ , cl- , ca2+ and p was determined in the final volume. diuretic action of extracts from phrygilanthus acutifolius was confirmed. aqueous and ethanol extracts at the dose of 200 mg/kg of body weight demonstrated more natriuretic activity than the others studied doses. on comparing them with furosemide, it was observed that the excretion of potassium in urine decrease, which suggested a diuretic action acting as potassium savers. further researches are necessary to elucidate the mechanism of diuretic action of the analyzed extracts.