Detección de respuesta linfoproliferativa en monos inoculados con virus dengue 4

a group of 6 cynomolgus monkeys was immunized with dengue 4 virus (h247 standard strain). 60 days after innoculation the cellular proliferation against the same serotype as well as against hetereologous serotypes 1 and 2 was measured. a proliferative response predominantly of the specific serotype and some cross reactivity were detected. these results showed a behavior of primates similar in some extent to that of human beings and mice regarding the specific serotype and cross serotype response to dengue virus.