Evaluación preliminar de la actividad antiviral del extracto acuoso de Phyllanthus orbicularis frente al virus VHS-1

the antiviral activity of the aqueous extract of phyllanthus orbicularis, a member of the euohorbiacea family, against the simple herpes virus type1 was evaluated in cellular culture, specifically in fibroblasts of human prepucium, and in an animal model, balb-c mice. the extracelullar effect of the extract on hiv-1 proved to be effective. a selective index of 44 was obtained, which shows a possible virucidal action on the particle. in the trial in vivo, the topical administration of the aqueous extract (12 mg/kg) reduced significantly the development of lesions in mice subcutaneously infected with hiv-1 (1 x 106 ufp). these results suggest the consideration of phyllanthus orbicularis as a possible anti-hiv-1 candidate