%0 Journal Article
%T Evaluaci¨®n preliminar de la actividad antiviral del extracto acuoso de Phyllanthus orbicularis frente al virus VHS-1
%A Vald¨¦s Garc¨ªa
%A Suria
%A del Barrio Alonso
%A Gloria
%A Guti¨¦rrez Gait¨¦n
%A Yamilet
%A Morier D¨ªaz
%A Luis
%J Revista Cubana de Medicina Tropical
%D 2003
%I Centro Nacional de Informaci¨®n de Ciencias M¨¦dicas
%X the antiviral activity of the aqueous extract of phyllanthus orbicularis, a member of the euohorbiacea family, against the simple herpes virus type1 was evaluated in cellular culture, specifically in fibroblasts of human prepucium, and in an animal model, balb-c mice. the extracelullar effect of the extract on hiv-1 proved to be effective. a selective index of 44 was obtained, which shows a possible virucidal action on the particle. in the trial in vivo, the topical administration of the aqueous extract (12 mg/kg) reduced significantly the development of lesions in mice subcutaneously infected with hiv-1 (1 x 106 ufp). these results suggest the consideration of phyllanthus orbicularis as a possible anti-hiv-1 candidate
%K plants
%K medicinal
%K clinical trials [method]
%K herpes virus
%K human
%K antiviral agents.
%U http://scielo.sld.cu/scielo.php?script=sci_abstract&pid=S0375-07602003000300006&lng=en&nrm=iso&tlng=en