Evaluación de la toxicidad in vitro del veneno del alacrán Rophalurus junceus a través de un ensayo celular

poison of blue scorpion (rophalurus junceus) is marketed as escozul. this natural product is used in treatment of different pathologies. objective: present paper evaluated the in vitro cytotoxic effect of this product in p3-x63/ag8/653 and dunning r3327-g tumor lines from murine myeloma and rat prostate, respectively. methods: cytotoxic effect was evaluated by means of cellular growing kinetics and the metabolic damage. doses of 1,10, 20, 50, 100, and 200 ìg/ml. results: poison had a cytostatic effect dependent of tumor line at issue. doses effective varied among the cellular lines assessed. we studied also stability of product stored during 30 days at temperatures of -20° and 4° c, evidenced the loss of biological activity. conclusions: we showed cytotoxic effect of crude poison of blue scorpion in cellular cultures.