%0 Journal Article
%T Evaluaci¨®n de la toxicidad in vitro del veneno del alacr¨¢n Rophalurus junceus a trav¨¦s de un ensayo celular
%A Hern¨¢ndez Betancourt
%A Oscar
%A Casado Hern¨¢ndez
%A Imilla
%A Iglesias Huerta
%A Eldris
%A Ram¨ªrez Labrada
%A Ariel
%A del Risco Ramos
%A Jorge
%A Rodr¨ªguez Pargas
%A Ayni
%J Revista Cubana de Investigaciones Biom£¿£¿dicas
%D 2009
%I ECIMED
%X poison of blue scorpion (rophalurus junceus) is marketed as escozul. this natural product is used in treatment of different pathologies. objective: present paper evaluated the in vitro cytotoxic effect of this product in p3-x63/ag8/653 and dunning r3327-g tumor lines from murine myeloma and rat prostate, respectively. methods: cytotoxic effect was evaluated by means of cellular growing kinetics and the metabolic damage. doses of 1,10, 20, 50, 100, and 200 ¨¬g/ml. results: poison had a cytostatic effect dependent of tumor line at issue. doses effective varied among the cellular lines assessed. we studied also stability of product stored during 30 days at temperatures of -20¡ã and 4¡ã c, evidenced the loss of biological activity. conclusions: we showed cytotoxic effect of crude poison of blue scorpion in cellular cultures.
%K rophalutus junceus
%K escozul
%K cytotoxic effect
%K scorpions
%K cellular lines
%K in vitro..
%U http://scielo.sld.cu/scielo.php?script=sci_abstract&pid=S0864-03002009000100006&lng=en&nrm=iso&tlng=en