Estudio de preformulación del citrato de dietilcarbamazina

the study of diethycarbamazine citrate preformulation with a view to finding uot the physico - chemical and tachnological characteristics of this pharmaceutical for further production of a 50 mg tablet was performed. this study included the determination of the size of micronized and non-micronized particles by optical microscopy in which the influence of size on the pharmaceutical dissolving in vitro was shown. drug - excipient incompatibility was analysed using differential scannig calorimetry and no interaction was found under experimental working conditions. other physico-chemical & technological properties of this pharmaceutical were examined.