Inactivacion de virus ADN envueltos en la producción de hemoderivados (Albúmina e Inmunoglobulinas)

inactivation of human herpes simplex virus i asa model of enveloped dna virus was studied in the stages of production of intramuscular/ intravenous inmunoglobulins and human albumin, in the phases of alcohol fractionation for obtaining these products, and in the methods of removal and/or inactivation implemented in manufacture, pasteurization and ion - exchange chromatography. the virus was quantified by cytophatic effects. the cumulative reduction values reported in this paper proved that the use of alcohol fractionation in cuba, as a variant of cohn - oncley method, combined with removal/inactivation procedures resulted in enveloped dna virus inactivation assuring high biological safety for albumin and immunoglobulins for their use in human beings.