%0 Journal Article
%T Inactivacion de virus ADN envueltos en la producci¨®n de hemoderivados (Alb¨²mina e Inmunoglobulinas)
%A Ruibal Brunet
%A Ignacio Juan
%A Noa Romero
%A Enrique
%A Mart¨ªn Garc¨ªa
%A Regina Zonia
%A Gonz¨¢lez Sosa
%A Nibaldo Luis
%A Ram¨ªrez Mas
%A Ana Teresa
%J Revista Cubana de Farmacia
%D 1999
%I ECIMED
%X inactivation of human herpes simplex virus i asa model of enveloped dna virus was studied in the stages of production of intramuscular/ intravenous inmunoglobulins and human albumin, in the phases of alcohol fractionation for obtaining these products, and in the methods of removal and/or inactivation implemented in manufacture, pasteurization and ion - exchange chromatography. the virus was quantified by cytophatic effects. the cumulative reduction values reported in this paper proved that the use of alcohol fractionation in cuba, as a variant of cohn - oncley method, combined with removal/inactivation procedures resulted in enveloped dna virus inactivation assuring high biological safety for albumin and immunoglobulins for their use in human beings.
%K dna
%K viral
%K herpes virus 1
%K human
%K serum albu-min
%K immunoglobulins
%K drug compoundings.
%U http://scielo.sld.cu/scielo.php?script=sci_abstract&pid=S0034-75151999000200002&lng=en&nrm=iso&tlng=en