Pasteurización de soluciones de inmunoglobulinas de uso intravenoso. 1.: Uso de azúcares como estabilizantes

pasteurization from the union of ii supernatants of 4 batches of normal plasma subjected to alcoholic fractionation was carried out using following stabilizers: sorbitol, sacarose and 30 % dextrose. the level of molecular aggregation wass determined by gel- filtration chromatography. sorbitol exhibited the best results with polymer formation ranging from 10 - 15 %; the values match those reported by other authors. according to who requirements, these polymers should be eliminated through other procedures for obtaining values under 10 %.