Asociación del virus herpes humano 8 y la hiperplasia linfoide nodular difusa del intestino delgado en la inmunodeficiencia variable común

the common variable immunodeficiency (cvid) is the more frequent primary immunodeficiency in clinical field and its presentation forms are very variable. we describe the case of a women presenting with adult cvid with chronic diarrhea syndrome, weight loss and diffuse lymphadenopathies, where the more marked immunologic features were a deep hypogammaglobulinemia of the three major kinds of immunoglobulins and numerical decrease of b cells (cd19+) and nk cells (cd3-cd56+) in peripheral blood. biopsy of small intestine obtained by video-assisted panendoscope, showed the presence of a multinodular lymphoid hyperplasia with partial atrophy of hairinesses. immunohistochemistry showed that nodules were high germinal centers with distribution of b cells (cd20+) and t cells (cd3+), similar to that of normal follicle. there was not differential expression of the k and λ light chains. the real time polymerase chain reaction (qrt-pcr) method detected many copies from the genome of type 8 human herpesvirus (vhh-8) (133 copies/μl of dna) in biopsy of intestinal nodule dna. vhh-8 infection may to be a significant factor in pathogenesis of lymphoproliferative disorders in patients presenting with cvid.