%0 Journal Article
%T Asociaci¨®n del virus herpes humano 8 y la hiperplasia linfoide nodular difusa del intestino delgado en la inmunodeficiencia variable com¨²n
%A Kokuina
%A Elena
%A Dom¨ªnguez ¨¢lvarez
%A Carlos
%A Noa Pedroso
%A Guillermo
%A Mart¨ªnez Rodr¨ªguez
%A Pedro Ariel
%A Kour¨ª Cardell¨¢
%A Vivian
%A Guti¨¦rrez P¨¦rez
%A Yoan
%A Chong L¨®pez
%A Agust¨ªn
%A Marrero Hern¨¢ndez
%A Delsy
%A P¨¦rez Rom¨¢n
%A Guillermo
%J Revista Cubana de Hematolog£¿-a, Inmunolog£¿-a y Hemoterapia
%D 2009
%I Editorial Ciencias M¨¦dicas
%X the common variable immunodeficiency (cvid) is the more frequent primary immunodeficiency in clinical field and its presentation forms are very variable. we describe the case of a women presenting with adult cvid with chronic diarrhea syndrome, weight loss and diffuse lymphadenopathies, where the more marked immunologic features were a deep hypogammaglobulinemia of the three major kinds of immunoglobulins and numerical decrease of b cells (cd19+) and nk cells (cd3-cd56+) in peripheral blood. biopsy of small intestine obtained by video-assisted panendoscope, showed the presence of a multinodular lymphoid hyperplasia with partial atrophy of hairinesses. immunohistochemistry showed that nodules were high germinal centers with distribution of b cells (cd20+) and t cells (cd3+), similar to that of normal follicle. there was not differential expression of the k and ¦Ë light chains. the real time polymerase chain reaction (qrt-pcr) method detected many copies from the genome of type 8 human herpesvirus (vhh-8) (133 copies/¦Ìl of dna) in biopsy of intestinal nodule dna. vhh-8 infection may to be a significant factor in pathogenesis of lymphoproliferative disorders in patients presenting with cvid.
%K common variable immunodeficiency (cvin)
%K human herpesvirus 8
%K intestine lymphoid hyperplasia.
%U http://scielo.sld.cu/scielo.php?script=sci_abstract&pid=S0864-02892009000300009&lng=en&nrm=iso&tlng=en