Análisis de algunas variables hematológicas, bioquímicas y clínicas en la anemia drepanocítica. Resultados preliminares

a total of 59 patients aged over 18 with sickle cell anemia were studied distributed in: group 1 (23) without acute thoracic syndrome (acs), priapism and malleolus ulcers; group 2 (39) with some of above complications. in group 2 there was a significant decrease of hemoglobin (hb) and the fetal hb and a platelet increase, lactic dehydrogenase (ldh), aspartate aminotransferase (ast), alanine aminotransferase (alt), total bilirubin (tb), alkaline phosphatase (aph), creatine kinase-mb (ck-mb) and of encephalic stroke frequency. the frequency of ast, malleolus ulcers and priapism in group 2 was of 83.3 %, 33.3 % and 50 %, respectively. the multiple linear regression analysis in all patients considering the ldh as a negati ve correlation significant for hb and the hto and positive for creatinine, ast, alt, tb, db, ib, aph and ck-mb. the pulmonary hypertension frequency was of 18.2 % (n= 10). these studies may be useful in the early diagnosis of hemolysis-related complications.