Anticorpos antinucleossomo e síndrome antifosfolipídica: estudo observacional

objective: to study the association of anti-nucleosome (anti-ncs) antibodies in primary antiphospholipid syndrome (aps) and the development of systemic lupus erythematosus (sle) during follow-up. materials and methods: thirty-six women with primary aps were evaluated prospectively for clinical features of systemic autoimmune diseases and for the presence of antiphospholipid antibodies, antinuclear antibodies and anti-ncs/chromatin antibodies. results: after a mean follow-up period of 45.7 months, anti-ncs/chromatin antibodies were detected in only one patient (2.8%), who developed features of sle including polyarthritis, lymphopenia, optic neuritis, multiple sclerosis-like lesions, and an autoantibody profile suggestive of sle. conclusion: the frequency of anti-ncs/chromatin antibodies in primary aps patients is very low, and they may be associated with the development of sle manifestations.