%0 Journal Article
%T Anticorpos antinucleossomo e s¨ªndrome antifosfolip¨ªdica: estudo observacional
%A Souza
%A Alexandre Wagner Silva de
%A Keusseyan
%A Silene Peres
%A Silva
%A Neusa Pereira da
%A Sato
%A Emilia Inoue
%A Andrade
%A Luis Eduardo Coelho
%J Revista Brasileira de Reumatologia
%D 2012
%I Sociedade Brasileira de Reumatologia
%R 10.1590/S0482-50042012000300006
%X objective: to study the association of anti-nucleosome (anti-ncs) antibodies in primary antiphospholipid syndrome (aps) and the development of systemic lupus erythematosus (sle) during follow-up. materials and methods: thirty-six women with primary aps were evaluated prospectively for clinical features of systemic autoimmune diseases and for the presence of antiphospholipid antibodies, antinuclear antibodies and anti-ncs/chromatin antibodies. results: after a mean follow-up period of 45.7 months, anti-ncs/chromatin antibodies were detected in only one patient (2.8%), who developed features of sle including polyarthritis, lymphopenia, optic neuritis, multiple sclerosis-like lesions, and an autoantibody profile suggestive of sle. conclusion: the frequency of anti-ncs/chromatin antibodies in primary aps patients is very low, and they may be associated with the development of sle manifestations.
%K antiphospholipid syndrome
%K systemic lupus erythematosus
%K anticardiolipin antibodies
%K lupus coagulation inhibitor nucleosomes.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0482-50042012000300006&lng=en&nrm=iso&tlng=en