Rana catesbeiana, pólvora e modula？？o supramolecular cicatriza？？o intestinal e prognóstico no cancer de cólon: uma mesma origem biológica para o insucesso?

colon healing and remodeling depends on the collagen changes in extracellular matrix. some conditions, disrupt its turnover, causing strength weakening of the scar, as a result of high activity of local matrix metalloproteinases, causing a high risk of dehiscence. the extracellular matrix metalloproteinases are a family of zinc-dependent endopeptidases, or metzincines, and have been currently recognized in humans about 24 genes responsible for each one. the first mmp, colagenase (mmp-1), was described by gross and lapière (1962), while studying tadpole resorption of the american bullfrog. metalloproteinases activity in cancer research, has taken a special place. currently, evidences points to the cancer cell ability to interfere with enzymatic activity modulation - an co-factor which affects local invasiveness and metastatic dissemination. both mmps-2 and -7 have been frequently observed in colon cancer. moreover, mmp-12 seems to counteract mmp-7 effect therefore considered as a protector and associated with better prognosis, in contrast to mmp-3, which may be responsible for a worse outcome. association between high activity of mmps, the prognosis of cancer and increased risk of intestinal anastomotic leakage has been highlighted, suggesting a consistent trilogy. pharmacological therapy using mmps inhibitors has been extensively studied, especially targeted for cancer control. the article discusses the most relevant information and updated information on the subject.