%0 Journal Article
%T Rana catesbeiana, p¨®lvora e modula£¿£¿o supramolecular cicatriza£¿£¿o intestinal e progn¨®stico no cancer de c¨®lon: uma mesma origem biol¨®gica para o insucesso?
%A Delabio-Ferraz
%A Edna
%A Aguiar Neto
%A Jo£¿o Pupo de
%A Takiya
%A Christina Maeda
%A Lacombe
%A Domingos Penna
%J Revista Brasileira de Coloproctologia
%D 2010
%I Scientific Electronic Library Online
%R 10.1590/S0101-98802010000200004
%X colon healing and remodeling depends on the collagen changes in extracellular matrix. some conditions, disrupt its turnover, causing strength weakening of the scar, as a result of high activity of local matrix metalloproteinases, causing a high risk of dehiscence. the extracellular matrix metalloproteinases are a family of zinc-dependent endopeptidases, or metzincines, and have been currently recognized in humans about 24 genes responsible for each one. the first mmp, colagenase (mmp-1), was described by gross and lapi¨¨re (1962), while studying tadpole resorption of the american bullfrog. metalloproteinases activity in cancer research, has taken a special place. currently, evidences points to the cancer cell ability to interfere with enzymatic activity modulation - an co-factor which affects local invasiveness and metastatic dissemination. both mmps-2 and -7 have been frequently observed in colon cancer. moreover, mmp-12 seems to counteract mmp-7 effect therefore considered as a protector and associated with better prognosis, in contrast to mmp-3, which may be responsible for a worse outcome. association between high activity of mmps, the prognosis of cancer and increased risk of intestinal anastomotic leakage has been highlighted, suggesting a consistent trilogy. pharmacological therapy using mmps inhibitors has been extensively studied, especially targeted for cancer control. the article discusses the most relevant information and updated information on the subject.
%K colorectal surgery
%K matriz metalloproteinases
%K wound healing
%K colon cancer
%K dehiscence.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0101-98802010000200004&lng=en&nrm=iso&tlng=en