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Trials

ISSN Print: 1745-6215

ISSN Online:

主页: http://www.trialsjournal.com

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Evaluating the effects of sevelamer carbonate on cardiovascular structure and function in chronic renal impairment in Birmingham: the CRIB-PHOS randomised controlled trial

Colin D Chue, Jonathan N Townend, Richard P Steeds, Charles J Ferro

The effects of centralised and specialised combined pharmacological and psychological intervention compared with decentralised and non-specialised treatment in the early course of severe unipolar and bipolar affective disorders - design of two randomised clinical trials

Lars Kessing, Hanne Hansen, Ellen Christensen, Henrik Dam, Christian Gluud, J？rn Wetterslev, the Early Intervention Affective Disorders (EIA) Group

Reporting of factorial trials of complex interventions in community settings: a systematic review

Alan A Montgomery, Margaret P Astin, Tim J Peters

Who is the research subject in cluster randomized trials in health research?

Andrew D McRae, Charles Weijer, Ariella Binik, Angela White, Jeremy M Grimshaw, Robert Boruch, Jamie C Brehaut, Allan Donner, Martin P Eccles, Raphael Saginur, Merrick Zwarenstein, Monica Taljaard

A traditional Chinese medicine versus Western combination therapy in the treatment of rheumatoid arthritis: two-stage study protocol for a randomized controlled trial

Chi Zhang, Miao Jiang, Aiping Lu

Improving delirium care in the intensive care unit: The design of a pragmatic study

Noll L Campbell, Babar A Khan, Mark Farber, Tiffany Campbell, Anthony J Perkins, Siu L Hui, Greg Abernathy, John Buckley, Regg Sing, Jason Tricker, Mohammad Zawahiri, Malaz A Boustani

Everolimus and long acting octreotide as a volume reducing treatment of polycystic livers (ELATE): study protocol for a randomized controlled trial

Melissa Chrispijn, Joost PH Drenth

The impact of dose of the angiotensin-receptor blocker valsartan on the post-myocardial infarction ventricular remodeling: study protocol for a randomized controlled trial

Young-Rak Cho, Young-Dae Kim, Tae-Ho Park, Kyungil Park, Jong-Sung Park, Heekyung Baek, Sun-Young Choi, Kee-Sik Kim, Taek-Jong Hong, Tae-Hyun Yang, Jin-Yong Hwang, Jong-Seon Park, Seung-Ho Hur, Sang-Gon Lee

Five years of Trials

Douglas G Altman, Iain Hrynaszkiewicz, Curt D Furberg, Jeremy M Grimshaw, Peter M Rothwell

Investigator experiences with financial conflicts of interest in clinical trials

Paula A Rochon, Melanie Sekeres, John Hoey, Joel Lexchin, Lorraine E Ferris, David Moher, Wei Wu, Sunila R Kalkar, Marleen Van Laethem, Andrea Gruneir, Jennifer Gold, James Maskalyk, David L Streiner, Nathan Taback, An-Wen Chan

Mums 4 Mums: structured telephone peer-support for women experiencing postnatal depression. Pilot and exploratory RCT of its clinical and cost effectiveness

Isabela Caramlau, Jane Barlow, Sukhdev Sembi, Kirstie McKenzie-McHarg, Chris McCabe

The efficacy and safety study of dietary supplement PURIAM110 on non-insulin taking Korean adults in the stage of pre-diabetes and diabetes mellitus: protocol for a randomized, double-blind, placebo-controlled, and multicenter trial-pilot study

Sunju Park, Jeong-Su Park, Hoyeon Go, Bo-Hyoung Jang, Yongcheol Shin, Seong-Gyu Ko

The cameroon mobile phone sms (CAMPS) trial: a protocol for a randomized controlled trial of mobile phone text messaging versus usual care for improving adherence to highly active anti-retroviral therapy

Lawrence Mbuagbaw, Lahana Thabane, Pierre Ongolo-Zogo, Richard T Lester, Edward Mills, Jimmy Volmink, David Yondo, Marie Essi, Renée-Cecile Bonono-Momnougui, Robert Mba, Jean Ndongo, Francois C Nkoa, Henri Ondoa

International Study to Predict Optimized Treatment for Depression (iSPOT-D), a randomized clinical trial: rationale and protocol

Leanne M Williams, A Rush, Stephen H Koslow, Stephen R Wisniewski, Nicholas J Cooper, Charles B Nemeroff, Alan F Schatzberg, Evian Gordon

The use of carer assisted adherence therapy for people with Parkinson's disease and their carers (CAAT-PARK): study protocol for a randomised controlled trial

David J Daley, Katherine HO Deane, Richard J Gray, Paul F Worth, Allan B Clark, Kanagasabesan Sabanathan, Michael Pfeil, Phyo K Myint

A comparison of specialist rehabilitation and care assistant support with specialist rehabilitation alone and usual care for people with Parkinson's living in the community: study protocol for a randomised controlled trial

Heather Gage, Sharlene Ting, Peter Williams, Karen Bryan, Julie Kaye, Beverly Castleton, Patrick Trend, Derick Wade

Effectiveness evaluation of an integrated automatic termomechanic massage system (SMATH？ system) in non-specific sub-acute and chronic low back pain - a randomized double-blinded controlled trial, comparing SMATH therapy versus sham therapy: study protocol for a randomized controlled trial

Paolo Buselli, Roberto Bosoni, Gabriella Busè, Paola Fasoli, Elide La Scala, Rita Mazzolari, Federica Zanetti, Sara Messina

Reduction of surgical site infection using a novel intervention (ROSSINI): study protocol for a randomised controlled trial

Thomas D Pinkney, David C Bartlett, William Hawkins, Tony Mak, Haney Youssef, Kaori Futaba, Gareth Harrison, Adrian Gheorghe, Jennifer M Bradbury, Melanie J Calvert, George Dowswell, Laura Magill, Val Redman, Sue Wilson, David Leaper, Dion G Morton, the West Midlands Research Collaborative

Stepped care treatment for depression and anxiety in primary care. a randomized controlled trial

Wike Seekles, Annemieke van Straten, Aartjan Beekman, Harm van Marwijk, Pim Cuijpers

Recruiting South Asians to a lifestyle intervention trial: experiences and lessons from PODOSA (Prevention of Diabetes & Obesity in South Asians)

Anne Douglas, Raj S Bhopal, Ruby Bhopal, John F Forbes, Jason MR Gill, Julia Lawton, John McKnight, Gordon Murray, Naveed Sattar, Anu Sharma, Jaakko Tuomilehto, Sunita Wallia, Sarah H Wild, Aziz Sheikh

Inhaled nitric oxide for the adjunctive therapy of severe malaria: Protocol for a randomized controlled trial

Michael Hawkes, Robert O Opoka, Sophie Namasopo, Christopher Miller, Kevin E Thorpe, James V Lavery, Andrea L Conroy, W Conrad Liles, Chandy C John, Kevin C Kain

Assessing the efficacy of the healthy eating and lifestyle programme (HELP) compared with enhanced standard care of the obese adolescent in the community: study protocol for a randomized controlled trial

Deborah Christie, Lee Hudson, Anne Mathiot, Tim J Cole, Saffron Karlsen, Anthony Kessel, Sanjay Kinra, Steve Morris, Irwin Nazareth, Ulla Sovio, Ian CK Wong, Russell M Viner

Endoscopic Saphenous harvesting with an Open CO2 System (ESOS) trial for coronary artery bypass grafting surgery: study protocol for a randomized controlled trial

Antonio Campanella, Laura Bergamasco, Luigia Macri, Sofia Asioli, Roger Devotini, Serenella Scipioni, Silvana Barbaro, Pietro Rispoli, Mauro Rinaldi

Efficacy of electroacupuncture at Zhongliao point (BL33) for mild and moderate benign prostatic hyperplasia: study protocol for a randomized controlled trial

Yang Wang, Zhishun Liu, Jinna Yu, Yulong Ding, Xuan Liu

Assessment of data quality in an international multi-centre randomised trial of coronary artery surgery

Lukasz J Krzych, Belinda Lees, Fiona Nugara, Winston Banya, Andrzej Bochenek, Jo Cook, David Taggart, Marcus D Flather

Self Management Activation Randomised Trial for Prostatitis (SMART-P): study protocol for a randomised controlled trial

Mark Rochester, James Armitage, Mark Sanders, Paula Christmas

Prevention of abdominal wound infection (PROUD trial, DRKS00000390): study protocol for a randomized controlled trial

Ulrike Heger, Sabine Voss, Phillip Knebel, Colette Doerr-Harim, Jens Neudecker, Christoph Schuhmacher, Eugen Faist, Markus K Diener, Meinhard Kieser, Christoph M Seiler, Markus W Büchler

Anger management for people with mild to moderate learning disabilities: Study protocol for a multi-centre cluster randomized controlled trial of a manualized intervention delivered by day-service staff

Paul Willner, Andrew Jahoda, John Rose, Biza Stenfert-Kroese, Kerenza Hood, Julia K Townson, Jacqueline Nuttall, David Gillespie, David Felce

Open reduction and internal fixation versus casting for highly comminuted and intra-articular fractures of the distal radius (ORCHID): protocol for a randomized clinical multi-center trial

Christoph Bartl, Dirk Stengel, Thomas Bruckner, Inga Rossion, Steffen Luntz, Christoph Seiler, Florian Gebhard

Project Masihambisane: a cluster randomised controlled trial with peer mentors to improve outcomes for pregnant mothers living with HIV

Mary-Jane Rotheram-Borus, Linda Richter, Heidi Van Rooyen, Alastair van Heerden, Mark Tomlinson, Alan Stein, Tamsen Rochat, Julia de Kadt, Nonhle Mtungwa, Lungile Mkhize, Lindo Ndlovu, Lungile Ntombela, W Scott Comulada, Katherine A Desmond, Erin Greco

Meropenem vs standard of care for treatment of late onset sepsis in children of less than 90 days of age: study protocol for a randomised controlled trial

Irja Lutsar, Ursula MT Trafojer, Paul T Heath, Tuuli Metsvaht, Joseph Standing, Susanna Esposito, Vincent de Cabre, Clarissa Oeser, Jean-Pierre Aboulker, The NeoMero Consortium

LigaSure Impact？ versus conventional dissection technique in pylorus-preserving pancreatoduodenectomy in clinical suspicion of cancerous tumours on the head of the pancreas: study protocol for a randomised controlled trial

Tobias Gehrig, Phillip Knebel, Verena Scheel, Ulf Hinz, Christoph M Seiler, Beat P Müller-Stich, Markus W Büchler, Carsten N Gutt

Failure to report protocol violations in clinical trials: a threat to internal validity?

Elizabeth A Sweetman, Gordon S Doig

The use of LiDCO based fluid management in patients undergoing hip fracture surgery under spinal anaesthesia: Neck of femur optimisation therapy - targeted stroke volume (NOTTS): study protocol for a randomized controlled trial

Matthew D Wiles, William JD Whiteley, Chris G Moran, Iain K Moppett

The OPERA trial: protocol for a randomised trial of an exercise intervention for older people in residential and nursing accommodation

Martin Underwood, Sandra Eldridge, Sallie Lamb, Rachel Potter, Bartley Sheehan, Anne-Marie Slowther, Stephanie Taylor, Margaret Thorogood, Scott Weich

Design, baseline characteristics, and retention of African American light smokers into a randomized trial involving biological data

Lisa Cox, Babalola Faseru, Matthew S Mayo, Ron Krebill, Tricia S Snow, Carrie A Bronars, Nicole L Nollen, Won S Choi, Kolawole S Okuyemi, Gary A Salzman, Neal L Benowitz, Rachel F Tyndale, Jasjit S Ahluwalia

Does clinical equipoise apply to cluster randomized trials in health research?

Ariella Binik, Charles Weijer, Andrew D McRae, Jeremy M Grimshaw, Robert Boruch, Jamie C Brehaut, Allan Donner, Martin P Eccles, Raphael Saginur, Monica Taljaard, Merrick Zwarenstein

Effects of Study Design and Allocation on participant behaviour - ESDA: study protocol for a randomized controlled trial

Kypros Kypri, Jim McCambridge, Amanda Wilson, John Attia, Paschal Sheeran, Steve Bowe, Tina Vater

European society of intensive care medicine study of therapeutic hypothermia (32-35°C) for intracranial pressure reduction after traumatic brain injury (the Eurotherm3235Trial)

Peter JD Andrews, Helen Sinclair, Claire G Battison, Kees H Polderman, Giuseppe Citerio, Luciana Mascia, Bridget A Harris, Gordon D Murray, Nino Stocchetti, David K Menon, Haleema Shakur, Daniel De Backer, the Eurotherm3235Trial collaborators

Homeopathy for Depression - DEP-HOM: study protocol for a randomized, partially double-blind, placebo controlled, four armed study

Ubiratan C Adler, Stephanie Krüger, Michael Teut, Rainer Lüdtke, Iris Bartsch, Lena Schützler, Friedericke Melcher, Stefan N Willich, Klaus Linde, Claudia M Witt

Periodontal treatment effects on endothelial function and cardiovascular disease biomarkers in subjects with chronic periodontitis: protocol for a randomized clinical trial

Jorge H Ramírez, Roger M Arce, Adolfo Contreras

The International Stroke Trial database

Peter AG Sandercock, Maciej Niewada, Anna Cz？onkowska, the International Stroke Trial Collaborative Group

Reconciling research and implementation in micro health insurance experiments in India: study protocol for a randomized controlled trial

Conor Doyle, Pradeep Panda, Ellen Van de Poel, Ralf Radermacher, David M Dror

A Depression Recognition and Treatment package for families living with Stroke (DepReT-Stroke): study protocol for a randomised controlled trial

Richard J Gray, Phyo K Myint, Frances Elender, Garry Barton, Michael Pfeil, Gill Price, Niki Wyatt, Garth Ravenhill, Ester Thomas, Jenny Jagger, Amelia Hursey, Kelly Waterfield, Sheila Hardy

Can an online clinical data management service help in improving data collection and data quality in a developing country setting?

Maarten A Wildeman, Jeroen Zandbergen, Andrew Vincent, Camelia Herdini, Jaap M Middeldorp, Renske Fles, Otilia Dalesio, Emile van der Donk, I Bing Tan

The effect of C1-esterase inhibitor on systemic inflammation in trauma patients with a femur fracture - The CAESAR study: study protocol for a randomized controlled trial

Marjolein Heeres, Tjaakje Visser, Karlijn JP van Wessem, Anky HL Koenderman, Paul FW Strengers, Leo Koenderman, Luke PH Leenen

Classic yin and yang tonic formula for osteopenia: study protocol for a randomized controlled trial

Feng Yang, De-Zhi Tang, Xue-Jun Cui, Jonathan D Holz, Qin Bian, Qi Shi, Yong-Jun Wang

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