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ISSN: 2333-9721
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Molecular Cancer

ISSN Print: 1476-4598

ISSN Online:

主页: http://www.molecular-cancer.com

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P-cadherin counteracts myosin II-B function: implications in melanoma progression

Koen Jacobs, Mireille Van Gele, Ramses Forsyth, Lieve Brochez, Barbara Vanhoecke, Olivier De Wever, Marc Bracke

Increased accumulation of hypoxia-inducible factor-1α with reduced transcriptional activity mediates the antitumor effect of triptolide

Zhao-Li Zhou, Zhi-Guo Luo, Bing Yu, Yi Jiang, Yi Chen, Jian-Ming Feng, Mei Dai, Lin-Jiang Tong, Zheng Li, Yuan-Chao Li, Jian Ding, Ze-Hong Miao

Macrophages may promote cancer growth via a GM-CSF/HB-EGF paracrine loop that is enhanced by CXCL12

Antonella Rigo, Michele Gottardi, Alberto Zamò, Pierluigi Mauri, Massimiliano Bonifacio, Mauro Krampera, Ernesto Damiani, Giovanni Pizzolo, Fabrizio Vinante

Pristimerin induces apoptosis in imatinib-resistant chronic myelogenous leukemia cells harboring T315I mutation by blocking NF-κB signaling and depleting Bcr-Abl

Zhongzheng Lu, Yanli Jin, Chun Chen, Juan Li, Qi Cao, Jingxuan Pan

Loss of PDEF, a prostate-derived Ets factor is associated with aggressive phenotype of prostate cancer: Regulation of MMP 9 by PDEF

Thomas R Johnson, Sweaty Koul, Binod Kumar, Lakshmipathi Khandrika, Sarah Venezia, Paul D Maroni, Randall B Meacham, Hari K Koul

BEX2 has a functional interplay with c-Jun/JNK and p65/RelA in breast cancer

Ali Naderi, Ji Liu, Luke Hughes-Davies

Cadmium down-regulates expression of XIAP at the post-transcriptional level in prostate cancer cells through an NF-κB-independent, proteasome-mediated mechanism

Konstantin Golovine, Peter Makhov, Robert G Uzzo, Alexander Kutikov, David J Kaplan, Eric Fox, Vladimir M Kolenko

The new platinum(IV) derivative LA-12 shows stronger inhibitory effect on Hsp90 function compared to cisplatin

Veronika Kvardova, Roman Hrstka, Dawid Walerych, Petr Muller, Eva Matoulkova, Veronika Hruskova, Dagmar Stelclova, Petr Sova, Borivoj Vojtesek

Hedgehog/Gli supports androgen signaling in androgen deprived and androgen independent prostate cancer cells

Mengqian Chen, Michael A Feuerstein, Elina Levina, Prateek S Baghel, Richard D Carkner, Matthew J Tanner, Michael Shtutman, Francis Vacherot, Stéphane Terry, Alexandre de la Taille, Ralph Buttyan

Organ-, inflammation- and cancer specific transcriptional fingerprints of pancreatic and hepatic stellate cells

Mert Erkan, Nadine Weis, Zheng Pan, Christian Schwager, Tamar Samkharadze, Xiaohua Jiang, Ute Wirkner, Nathalia A Giese, Wilhelm Ansorge, Jürgen Debus, Peter E Huber, Helmut Friess, Amir Abdollahi, J？rg Kleeff

The transcription factor RBP-J-mediated signaling is essential for dendritic cells to evoke efficient anti-tumor immune responses in mice

Fan Feng, Yao-Chun Wang, Xing-Bin Hu, Xiao-Wei Liu, Gang Ji, Yun-Ru Chen, Lin Wang, Fei He, Guo-Rui Dou, Liang Liang, Hong-Wei Zhang, Hua Han

Wnt-11 promotes neuroendocrine-like differentiation, survival and migration of prostate cancer cells

Pinar Uysal-Onganer, Yoshiaki Kawano, Mercedes Caro, Marjorie M Walker, Soraya Diez, R Siobhan Darrington, Jonathan Waxman, Robert M Kypta

Specific effects of bortezomib against experimental malignant pleural effusion: a preclinical study

Ioannis Psallidas, Sophia P Karabela, Charalampos Moschos, Taylor P Sherrill, Androniki Kollintza, Sophia Magkouta, Panagiota Theodoropoulou, Charis Roussos, Timothy S Blackwell, Ioannis Kalomenidis, Georgios T Stathopoulos

The mitochondria-independent cytotoxic effect of nelfinavir on leukemia cells can be enhanced by sorafenib-mediated mcl-1 downregulation and mitochondrial membrane destabilization

Ansgar Brüning, Martina Rahmeh, Andrea Gingelmaier, Klaus Friese

HDAC2 attenuates TRAIL-induced apoptosis of pancreatic cancer cells

Susanne Schüler, Petra Fritsche, Sandra Diersch, Alexander Arlt, Roland M Schmid, Dieter Saur, Günter Schneider

Regulation of MCP-1 chemokine transcription by p53

Katrin Hacke, Bladimiro Rincon-Orozco, Gilles Buchwalter, Simone Y Siehler, Bohdan Wasylyk, Lisa Wiesmüller, Frank R？sl

HSP90 inhibitor, celastrol, arrests human monocytic leukemia cell U937 at G0/G1 in thiol-containing agents reversible way

Bin Peng, Limin Xu, Fanfan Cao, Tingxuan Wei, Chunxin Yang, Georges Uzan, Denghai Zhang

Identification of 5 novel genes methylated in breast and other epithelial cancers

Victoria K Hill, Luke B Hesson, Temuujin Dansranjavin, Ashraf Dallol, Ivan Bieche, Sophie Vacher, Stella Tommasi, Timothy Dobbins, Dean Gentle, David Euhus, Cheryl Lewis, Reinhard Dammann, Robyn L Ward, John Minna, Eammon R Maher, Gerd P Pfeifer, Farida Latif

PI3Kp110-, Src-, FAK-dependent and DOCK2-independent migration and invasion of CXCL13-stimulated prostate cancer cells

Christelle P El Haibi, Praveen K Sharma, Rajesh Singh, Paul R Johnson, Jill Suttles, Shailesh Singh, James W Lillard

MicroRNA-184 inhibits neuroblastoma cell survival through targeting the serine/threonine kinase AKT2

Niamh H Foley, Isabella M Bray, Amanda Tivnan, Kenneth Bryan, Derek M Murphy, Patrick G Buckley, Jacqueline Ryan, Anne O'Meara, Maureen O'Sullivan, Raymond L Stallings

Intracellular targets of RGDS peptide in melanoma cells

Maria Aguzzi, Paola Fortugno, Claudia Giampietri, Gianluca Ragone, Maurizio C Capogrossi, Antonio Facchiano

Prosaposin down-modulation decreases metastatic prostate cancer cell adhesion, migration, and invasion

Siyi Hu, Nathalie Delorme, Zhenzhen Liu, Tao Liu, Cruz Velasco-Gonzalez, Jone Garai, Ashok Pullikuth, Shahriar Koochekpour

An evolved ribosome-inactivating protein targets and kills human melanoma cells in vitro and in vivo

Melissa C Cheung, Leigh Revers, Subodini Perampalam, Xin Wei, Reza Kiarash, David E Green, Aws Abdul-Wahid, Jean Gariépy

ΔNp63 transcriptionally regulates ATM to control p53 Serine-15 phosphorylation

Ashley L Craig, Jitka Holcakova, Lee E Finlan, Marta Nekulova, Roman Hrstka, Nuri Gueven, James DiRenzo, Graeme Smith, Ted R Hupp, Borivoj Vojtesek

Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition

María M Caffarel, Clara Andradas, Emilia Mira, Eduardo Pérez-Gómez, Camilla Cerutti, Gema Moreno-Bueno, Juana M Flores, Isabel García-Real, José Palacios, Santos Ma？es, Manuel Guzmán, Cristina Sánchez

Tumor promoting effects of CD95 signaling in chemoresistant cells

Elisabet Ametller, Susana García-Recio, Domizziana Costamagna, Cristina Mayordomo, Patricia Fernández-Nogueira, Neus Carbó, Eva Pastor-Arroyo, Pedro Gascón, Vanessa Almendro

A yeast-based genomic strategy highlights the cell protein networks altered by FTase inhibitor peptidomimetics

Giampiero Porcu, Cathal Wilson, Daniele Di Giandomenico, Antonella Ragnini-Wilson

New-generation taxoid SB-T-1214 inhibits stem cell-related gene expression in 3D cancer spheroids induced by purified colon tumor-initiating cells

Galina I Botchkina, Edison S Zuniga, Manisha Das, Yuan Wang, Haichao Wang, Shu Zhu, Anne G Savitt, Rebecca A Rowehl, Yan Leyfman, Jingfang Ju, Kenneth Shroyer, Iwao Ojima

Gene expression profiling of mouse p53-deficient epidermal carcinoma defines molecular determinants of human cancer malignancy

Ramón García-Escudero, Ana B Martínez-Cruz, Mirentxu Santos, Corina Lorz, Carmen Segrelles, Guillermo Garaulet, Cristina Saiz-Ladera, Clotilde Costa, águeda Buitrago-Pérez, Marta Due？as, Jesús M Paramio

TWIST1 promotes invasion through mesenchymal change in human glioblastoma

Svetlana A Mikheeva, Andrei M Mikheev, Audrey Petit, Richard Beyer, Robert G Oxford, Leila Khorasani, John-Patrick Maxwell, Carlotta A Glackin, Hiroaki Wakimoto, Inés González-Herrero, Isidro Sánchez-García, John R Silber, Philip J Horner, Robert C Rostomily

Tumor cell behaviour modulation by mesenchymal stromal cells

Lucia Kucerova, Miroslava Matuskova, Kristina Hlubinova, Veronika Altanerova, Cestmir Altaner

Benzo[a]pyrene diol epoxide suppresses retinoic acid receptor-β2 expression by recruiting DNA (cytosine-5-)-methyltransferase 3A

Fei Ye, Xiao-Chun Xu

ISG20L1 is a p53 family target gene that modulates genotoxic stress-induced autophagy

Kathryn G Eby, Jennifer M Rosenbluth, Deborah J Mays, Clayton B Marshall, Christopher E Barton, Seema Sinha, Kimberly N Johnson, Luojia Tang, Jennifer A Pietenpol

Silencing of TESTIN by dense biallelic promoter methylation is the most common molecular event in childhood acute lymphoblastic leukaemia

Robert J Weeks, Ursula R Kees, Sarah Song, Ian M Morison

The Wnt inhibitory factor 1 restoration in prostate cancer cells was associated with reduced tumor growth, decreased capacity of cell migration and invasion and a reversal of epithelial to mesenchymal transition

David S Yee, Yaxiong Tang, Xuesen Li, Zhongbo Liu, Yi Guo, Samia Ghaffar, Peter McQueen, Dash Atreya, Jun Xie, Anne R Simoneau, Bang H Hoang, Xiaolin Zi

Chemotherapeutic drugs sensitize human renal cell carcinoma cells to ABT-737 by a mechanism involving the Noxa-dependent inactivation of Mcl-1 or A1

Henry Zall, Arnim Weber, Robert Besch, Niko Zantl, Georg H？cker

VHZ is a novel centrosomal phosphatase associated with cell growth and human primary cancers

Jing Tang, Cheng Tan, Jie Li, Md Monowarul Siddique, Ke Guo, Siew Chan, Jung Park, Wan Tay, Zhi Huang, Wen Li, Jian Chen, Qi Zeng

Gemcitabine intercellular diffusion mediated by gap junctions: new implications for cancer therapy

Sylvine Cottin, Karim Ghani, Pedro de Campos-Lima, Manuel Caruso

Extracellular matrix rigidity modulates neuroblastoma cell differentiation and N-myc expression

Wilbur A Lam, Lizhi Cao, Vaibhavi Umesh, Albert J Keung, Shamik Sen, Sanjay Kumar

MicroRNAs involvement in fludarabine refractory chronic lymphocytic leukemia

Manuela Ferracin, Barbara Zagatti, Lara Rizzotto, Francesco Cavazzini, Angelo Veronese, Maria Ciccone, Elena Saccenti, Laura Lupini, Andrea Grilli, Cristiano De Angeli, Massimo Negrini, Antonio Cuneo

Tumor suppressor FLCN inhibits tumorigenesis of a FLCN-null renal cancer cell line and regulates expression of key molecules in TGF-β signaling

Seung-Beom Hong, HyoungBin Oh, Vladimir A Valera, Jaime Stull, Duy-Tan Ngo, Masaya Baba, Maria J Merino, W Marston Linehan, Laura S Schmidt

Nerve growth factor promotes breast cancer angiogenesis by activating multiple pathways

Rodrigue Romon, Eric Adriaenssens, Chann Lagadec, Emmanuelle Germain, Hubert Hondermarck, Xuefen Le Bourhis

ROS accumulation and IGF-IR inhibition contribute to fenofibrate/PPARα -mediated inhibition of Glioma cell motility in vitro

Justyna Drukala, Katarzyna Urbanska, Anna Wilk, Maja Grabacka, Ewa Wybieralska, Luis Del Valle, Zbigniew Madeja, Krzysztof Reiss

Upregulation of Id1 by Epstein-Barr Virus-encoded LMP1 confers resistance to TGFβ-mediated growth inhibition

Angela KF Lo, Christopher W Dawson, Kwok W Lo, Yanxing Yu, Lawrence S Young

Inositol 1,4,5-trisphosphate-induced Ca2+ signalling is involved in estradiol-induced breast cancer epithelial cell growth

Cécilia Szatkowski, Jan B Parys, Halima Ouadid-Ahidouch, Fabrice Matifat

A novel role of the aryl hydrocarbon receptor (AhR) in centrosome amplification - implications for chemoprevention

Nina Korzeniewski, Sarah Wheeler, Payel Chatterjee, Anette Duensing, Stefan Duensing

Interaction between circulating galectin-3 and cancer-associated MUC1 enhances tumour cell homotypic aggregation and prevents anoikis

Qicheng Zhao, Monica Barclay, John Hilkens, Xiuli Guo, Hannah Barrow, Jonathan M Rhodes, Lu-Gang Yu

Cyclin K and cyclin D1b are oncogenic in myeloma cells

Véronique Marsaud, Guergana Tchakarska, Geoffroy Andrieux, Jian-Miao Liu, Doulaye Dembele, Bernard Jost, Joanna Wdzieczak-Bakala, Jack-Michel Renoir, Brigitte Sola

A randomized, double-blind, placebo-controlled study of high-dose bosentan in patients with stage IV metastatic melanoma receiving first-line dacarbazine chemotherapy

Richard F Kefford, Philip R Clingan, Benjamin Brady, Andrea Ballmer, Adele Morganti, Peter Hersey

Osteopontin selectively regulates p70S6K/mTOR phosphorylation leading to NF-κB dependent AP-1-mediated ICAM-1 expression in breast cancer cells

Mansoor Ahmed, Gopal C Kundu

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