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ISSN: 2333-9721
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主页: https://journals.plos.org/ploscompbiol/

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Systems Level Analysis of Systemic Sclerosis Shows a Network of Immune and Profibrotic Pathways Connected with Genetic Polymorphisms

Casey S. Greene,J. Matthew Mahoney,Jaclyn Taroni,Michael L. Whitfield,Monique E. Hinchcliff,Patricia A. Pioli,Tammara A. Wood,Viktor Martyanov

Bayesian History Matching of Complex Infectious Disease Models Using Emulation: A Tutorial and a Case Study on HIV in Uganda

Ian R. Vernon,Ioannis Andrianakis,Jeremy E. Oakley,Michael Goldstein,Nicky McCreesh,Rebecca N. Nsubuga,Richard G. White,Trevelyan J. McKinley

Ten Simple (Empirical) Rules for Writing Science

Cody J. Weinberger,James A. Evans,Stefano Allesina

What Makes a Protein Sequence a Prion?

Frederic Rousseau,Joost Schymkowitz,Raimon Sabate,Salvador Ventura

Ten Simple Rules for Creating a Good Data Management Plan

William K. Michener

Mechanism of Focal Adhesion Kinase Mechanosensing

Agnieszka Bronowska,Camilo Aponte-Santamaría,Frauke Gr？ter,Jakob Tómas Bullerjahn,Jing Zhou,Sebastian Sturm

Oxygen-Driven Tumour Growth Model: A Pathology-Relevant Mathematical Approach

Alessandro P. S. de Moura,James W. T. Yates,Jennifer I. Hare,Juan A. Delgado-SanMartin

Doubly Bayesian Analysis of Confidence in Perceptual Decision-Making

Bahador Bahrami,Dan Bang,Laurence Aitchison,Peter E. Latham

pMD-Membrane: A Method for Ligand Binding Site Identification in Membrane-Bound Proteins

Abdallah Sayyed-Ahmad,Alemayehu A. Gorfe,Priyanka Prakash

Parsimonious Model of Vascular Patterning Links Transverse Hormone Fluxes to Lateral Root Initiation: Auxin Leads the Way, while Cytokinin Levels Out

Ari Pekka M？h？nen,Athanasius F. M. Marée,Hanna Help-Rinta-Rahko,Riccardo Siligato,Sedeer el-Showk,Tiina Blomster,Ver？nica A. Grieneisen

Quantifying Spike Train Oscillations: Biases, Distortions and Solutions

Ayala Matzner,Izhar Bar-Gad

Multiplex Eukaryotic Transcription (In)activation: Timing, Bursting and Cycling of a Ratchet Clock Mechanism

Aleksandra Tomaszewska,Carsten Carlberg,Frank J. Bruggeman,Hans V. Westerhoff,Katja N. Rybakova,Martijn J. Moné

ApoE4-specific Misfolded Intermediate Identified by Molecular Dynamics Simulations

Benfeard Williams II,Jhuma Das,Marino Convertino,Nikolay V. Dokholyan

Thermal Stabilization of Dihydrofolate Reductase Using Monte Carlo Unfolding Simulations and Its Functional Consequences

Anna Whitney,Eugene I. Shakhnovich,Jaie C. Woodard,Jian Tian

Non-linear Membrane Properties in Entorhinal Cortical Stellate Cells Reduce Modulation of Input-Output Responses by Voltage Fluctuations

Fernando R. Fernandez,John A. White,Paola Malerba

Cell-Specific Cardiac Electrophysiology Models

Andrew C. Zygmunt,Armen R. Kherlopian,David J. Christini,Francis A. Ortega,Trine Krogh-Madsen,Willemijn Groenendaal

What Is the Most Realistic Single-Compartment Model of Spike Initiation?

Romain Brette

Structural Refinement of Proteins by Restrained Molecular Dynamics Simulations with Non-interacting Molecular Fragments

Beno？t Roux,Giacomo Fiorin,Klaus Schulten,Rong Shen,Shahidul M. Islam,Wei Han

Comparisons of Allergenic and Metazoan Parasite Proteins: Allergy the Price of Immunity

Colin M Fitzsimmons,David W Dunne,Edridah Tukahebwa,Edward J Farnell,Janet M Thornton,Nicholas Furnham,Nidhi Tyagi,Rick M Maizels,Stephanie Ryan

GOBLET: The Global Organisation for Bioinformatics Learning, Education and Training

Celia W. G. van Gelder,Erik Bongcam-Rudloff,Fran Lewitter,GOBLET Consortium,Manuel Corpas,Maria Victoria Schneider,Michelle E. Brazas,Nicola Mulder,Pascale Gaudet,Patricia M. Palagi,Teresa K. Atwood

Emergence of Shared Intentionality Is Coupled to the Advance of Cumulative Culture

Jonathan Newton,Simon D. Angus

The Trigger Factor Chaperone Encapsulates and Stabilizes Partial Folds of Substrate Proteins

Alireza Mashaghi,Jocelyne Vreede,Kushagra Singhal,Peter G. Bolhuis,Sander J. Tans

Orientation Selectivity in Inhibition-Dominated Networks of Spiking Neurons: Effect of Single Neuron Properties and Network Dynamics

Sadra Sadeh,Stefan Rotter

Analysis of Individual Protein Regions Provides Novel Insights on Cancer Pharmacogenomics

Adam Godzik,Eduard Porta Pardo

Cultured Cortical Neurons Can Perform Blind Source Separation According to the Free-Energy Principle

Kiyoshi Kotani,Takuya Isomura,Yasuhiko Jimbo

Ligand-Target Prediction by Structural Network Biology Using nAnnoLyze

Francisco Martínez-Jiménez,Marc A. Marti-Renom

Local Geometry and Evolutionary Conservation of Protein Surfaces Reveal the Multiple Recognition Patches in Protein-Protein Interactions

Alessandra Carbone,Elodie Laine

Improved Estimation and Interpretation of Correlations in Neural Circuits

Alexander S. Ecker,Andreas S. Tolias,Dimitri Yatsenko,Emmanouil Froudarakis,Kre？imir Josi？,R. James Cotton

Kinetically-Defined Component Actions in Gene Repression

Carson C. Chow,Geoffery B. Storchan,Kelsey K. Finn,S. Stoney Simons Jr.,Xiaoyan Sheng,Xinping Lu

Integrating Interactive Computational Modeling in Biology Curricula

Christine E. Cutucache,Jim A. Rogers,Joshua J. Larson,Lauren M. Dahlquist,Tomá？ Helikar,Tyler A. Herek

When Less Is More: Non-monotonic Spike Sequence Processing in Neurons

Birk Urmersbach,Hinrich Arnoldt,Holger Taschenberger,Marc Timme,Shuwen Chang,Sven Jahnke

HIV Competition Dynamics over Sexual Networks: First Comer Advantage Conserves Founder Effects

Bence Ferdinandy,Enys Mones,Tamás Vicsek,Viktor Müller

Resting-State Temporal Synchronization Networks Emerge from Connectivity Topology and Heterogeneity

Adrián Ponce-Alvarez,Dante Mantini,Gian Luca Romani,Gustavo Deco,Maurizio Corbetta,Patric Hagmann

Heterogeneous CD8+ T Cell Migration in the Lymph Node in the Absence of Inflammation Revealed by Quantitative Migration Analysis

Andrea J. Liu,Christopher A. Hunter,David A. Christian,Edward J. Banigan,Tajie H. Harris

Computing the Local Field Potential (LFP) from Integrate-and-Fire Network Models

Alberto Mazzoni,Anders Lansner,Gaute T. Einevoll,Henrik Lindén,Hermann Cuntz,Stefano Panzeri

Improved Statistical Methods Enable Greater Sensitivity in Rhythm Detection for Genome-Wide Data

Aaron R. Dinner,Alan L. Hutchison,Andrew H. Chiang,Herman Gudjonson,Mark Maienschein-Cline,Neil Bahroos,Ravi Allada,S. M. Ali Tabei

Microbial Forensics: Predicting Phenotypic Characteristics and Environmental Conditions from Large-Scale Gene Expression Profiles

Ilias Tagkopoulos,Minseung Kim,Violeta Zorraquino

Asymmetric Genome Organization in an RNA Virus Revealed via Graph-Theoretical Analysis of Tomographic Data

Eric C. Dykeman,James A. Geraets,Neil A. Ranson,Peter G. Stockley,Reidun Twarock

Dynamic Network Drivers of Seizure Generation, Propagation and Termination in Human Neocortical Epilepsy

Ankit N. Khambhati,Brian Litt,Brian S. Oommen,Danielle S. Bassett,Kathryn A. Davis,Stephanie H. Chen,Timothy H. Lucas

The Essential Complexity of Auditory Receptive Fields

Ivar L. Thorson,Jean Liénard,Stephen V. David

At the Edge of Chaos: How Cerebellar Granular Layer Network Dynamics Can Provide the Basis for Temporal Filters

Christian R？ssert,John Porrill,Paul Dean

Signaling and Adaptation Modulate the Dynamics of the Photosensoric Complex of Natronomonas pharaonis

Armen Y. Mulkidjanian,Daniel Klose,Heinz-Jürgen Steinhoff,Johann P. Klare,Konstantin V. Shaitan,Martin Engelhard,Philipp S. Orekhov

Discovering Anti-platelet Drug Combinations with an Integrated Model of Activator-Inhibitor Relationships, Activator-Activator Synergies and Inhibitor-Inhibitor Synergies

Darren J. Fitzpatrick,Denis C. Shields,Federica Lombardi,Fergal P. Casey,Kalyan Golla,Niamh Moran

Transcriptional Dynamics Reveal Critical Roles for Non-coding RNAs in the Immediate-Early Response

Ahmad M. N. Alhendi,Alistair R. R. Forrest,Carsten O. Daub,Colin A. Semple,Erik Arner,Hideya Kawaji,Levon M. Khachigian,Mariko Okada-Hatakeyama,Masayoshi Itoh,Piero Carninci,Shigeyuki Magi,Stuart Aitken,Timo Lassmann,Yoshihide Hayashizaki,the FANTOM Consortium

Critical Roles of the Direct GABAergic Pallido-cortical Pathway in Controlling Absence Seizures

Daqing Guo,Dezhong Yao,Jingling Ma,Min Li,Mingming Chen,Peng Xu,Shengdun Wu,Tao Ma,Yan Cui,Yang Xia

Machine Learning Methods Enable Predictive Modeling of Antibody Feature:Function Relationships in RV144 Vaccinees

Amy W. Chung,Chris Bailey-Kellogg,Donald Francis,Galit Alter,Ickwon Choi,Jaranit Kaewkungwal,Jerome H. Kim,Margaret E. Ackerman,Merlin L. Robb,Nelson L. Michael,Punnee Pitisuttithum,Robert J. O'Connell,Sorachai Nitayaphan,Supachai Rerks-Ngarm,Todd J. Suscovich

Mining Host-Pathogen Protein Interactions to Characterize Burkholderia mallei Infectivity Mechanisms

Anders Wallqvist,David DeShazer,Jaques Reifman,Keehwan Kwon,Nela Zavaljevski,Rembert Pieper,Seesandra V. Rajagopala,Vesna Memi？evi？

ISCB Ebola Award for Important Future Research on the Computational Biology of Ebola Virus

Bonnie Berger,Burkhard Rost,Diane Kovats,Michal Linial,Pardis Sabeti,Peter D. Karp,Thomas Lengauer,Winston Hide

A Probabilistic Palimpsest Model of Visual Short-term Memory

Loic Matthey,Paul M. Bays,Peter Dayan

Neuromechanistic Model of Auditory Bistability

Elyse Sussman,James Rankin,John Rinzel

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