Background: Shoulder dysfunction after mastectomy is common and can significantly reduce a patient's quality of life and upper limb functionality. Symptoms include discomfort, limited range of motion, and functional limitations. Anterior chest wall stiffness may impede optimal healing, even though conventional rehabilitation primarily targets shoulder strengthening and mobility. Aim: Was to assess stretching and chest mobilization have been suggested as supplem...

Biochemistry 

Background:？Total thyroidectomy is a common surgical procedure necessitating lifelong levothyroxine replacement therapy to maintain metabolic homeostasis; however, thyroid hormone imbalances profoundly affect skeletal muscle function. Objective: To assess hand grip strength among post-thyroidectomy patients on hormonal therapy. Patients and methods:？A cross-sectional observational study was conducted in an outpatient clinical setting. Particip...

Biochemistry 

Background: Stroke prevalence represents a significant global burden, serving as a key cause of long-term disability and a catalyst for increased medical complications, affecting daily life and increasing health risks. Objective: We aimed to explore the impact of pressure threshold loading training on the quality of life (QOL) among post-stroke survivors. Material and methods: This randomized controlled trial involved 34 strok...

Biochemistry 

Background: Postoperative septic arthritis is an uncommon but potentially devastating complication following anterior cruciate ligament reconstruction (ACLR). Hamstring autograft use, concomitant open procedures, drain usage, and prior ipsilateral knee surgery have been identified as risk factors. Staphylococci account for up to 90% of causative organisms. Presoaking of the autograft in vancomycin has recently emerged as a promising prophylactic strategy. Aim: T...

Biochemistry 

Background: Fibromyalgia (FM) is frequently associated with musculoskeletal (MSK) comorbidities, however, the extent to which chondromalacia patella (CMP) is associated with patellofemoral arthritis (PFA) in FM patients has not been well established. Objective: This study aimed to assess the frequency of PFA among patients with FM diagnosed with CMP using both clinical and radiological assessments. Patients and Methods: This c...

Biochemistry 

Background: Retinopathy of prematurity (ROP) is a disease of preterm infants with incomplete retinal vascular development and remains a major cause of childhood blindness worldwide despite advances in neonatal care. Early detection in high-risk infants is essential. ROP is a biphasic fibrovascular disorder, beginning with vascular arrest followed by pathological neovascularization. Major risk factors include low birth weight, low gestational age, fluctuating oxygen exposure, res...

Biochemistry 

Background: Lower abdominal surgeries like inguinal hernia repairs are frequent pediatric procedures where effective analgesia is vital for day-case recovery. Regional anesthesia is increasingly used to reduce opioid consumption and shorten hospital stays. Objective: This study aimed to determine the effect of a single preoperative dose of intravenous ibuprofen on the time to first postoperative rescue analgesia compared to ultrasound-guided transversus abdomin...

Biochemistry 

Background: Dexmedetomidine (DEX) and dexamethasone (DEXA) are increasingly utilized as anesthetic adjuvant to improve block quality and extend postoperative analgesia. Objective: This research aimed to evaluate the efficacy and safety of DEX and DEXA as lidocaine 2%-adjuvants in patients undergoing elective vitreoretinal (VR) surgery under peribulbar block (PBB). Patients and methods: This randomized, triple-blind trial enrolled 90 patients (18–70 years, both sexes) undergoing elective VR sur...

Biochemistry 

Background: Breast cancer is the most common malignancy in women and exhibits marked biological heterogeneity with variable clinical outcomes. Inflammatory chemokines, particularly CXCL5, contribute to tumor progression through activation of CXCR2 signaling, promoting proliferation, angiogenesis, epithelial–mesenchymal transition, and recruitment of tumor-associated neutrophils. While CXCL5 is primarily a secreted cytoplasmic protein, emerging evidence suggests that altered subc...

Biochemistry 

Background: Glanzmann thrombasthenia is a rare inherited platelet function disorder caused by qualitative or quantitative defects in the integrin αIIbβ3 receptor, resulting in impaired platelet aggregation and a lifelong tendency to mucocutaneous bleeding. Although current therapeutic strategies such as platelet transfusion and recombinant activated factor VII have improved patient outcomes, variability in treatment response remains a significant clinical challenge. Increasing e...

Biochemistry