purpose: in order to assess the occurrence of adverse ocular effects of antipsychotic drugs, we sought to evaluate intraocular pressure of schizophrenic patients treated with psychiatric medications. methods: twenty-eight outpatients with dsm-iv diagnosis of schizophrenia who met both the inclusion and exclusion criteria were submitted to an ophthalmic evaluation for ocular abnormalities which included intraocular pressure measurement with goldmann applanation tonometry. results: raised intraocular pressure was found in three patients (11%). abnormality in cup-disc ratio was seen in only one patient with cup-disc ratio asymmetry of 0.4. all these four patients were taking only ziprasidone. conclusions: patients using ziprasidone were found to have abnormalities in both intraocular pressure and cup-disc ratio.