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Oct 31, 2024Open    Access

Statistical Analysis of Cardiovascular Diseases Dataset of BRFSS

Sushant Kumar Gupta,Ashank Anshuman,Aakarshit Uppal,Indrajit Mukherjee
Cardiovascular Diseases (CVDs) remain a leading cause of death in the United States. These diseases, including coronary heart disease, heart attack, and stroke, pose significant health risks. Accurate prediction of CVD probability can aid in prevention and management. To address this challenge, we analyzed data from the Behavioral Risk Factor Surveillance System (BRFSS) spanning 1995-2017. We developed innovative methods to handle missing data and normalize values. Deep learning models were empl...
Open Access Library J.   Vol.11, 2024
Doi:10.4236/oalib.1112281


Oct 18, 2024Open    Access

Two-Sample Mendelian Randomization Analysis of the Causal Relationship between Intestinal Flora and Childhood Obesity

Dewei Xu,Hong Wang
Objective: To evaluate the potential causal relationship between 182 gut microbiota and childhood obesity by two-sample Mendelian randomization. Methods: The data source was the summary data of genome-wide association study (GWAS), and 182 intestinal microbiota contained 874 single nucleotide diversity (SNPs). The childhood obesity data contained 2,442,739 SNPs. Mendelian randomization analysis was performed using three methods: inverse variance weighting (IVW), weighted median,...
Open Access Library J.   Vol.11, 2024
Doi:10.4236/oalib.1112342


Jul 25, 2024Open    Access

Smartphone Oximeter SpO2 Integrated Measurement

Yahweh Van Ram Sri
Smartphone-based Oximetry device as early healthcare detection is a technological frontier. Smartphone oximetry devices offer a convenient method for remote SpO2 monitoring and early detection of critical health issues, especially during pandemics when vital indicators are necessary. Rising healthcare demands, and the COVID-19 pandemic are recent causes necessitating the prevalence for accessible early detection tools. This research investigates smartphone oximetry device as a conveni...
Open Access Library J.   Vol.11, 2024
Doi:10.4236/oalib.1111580


Mar 31, 2023Open    Access

Identification of Hub Genes in Prostate Cancer by Bioinformatics Analysis

Rui Zhang, Wenhua Guo, Luhong Yang
Objective: To identify the candidate hub genes of prostate cancer (PCa) and investigate the relevance of the genes on the development of PCa by bioinformatics methods. Methods: The mRNA expression profile datasets GSE103512 was collected from GEO database, and find out differential expression genes (DEGs) between PCa and normal tissues using the GEO2R tool. Subsequently, to further elucidate the interaction of DEGs and screen the hub genes, we conducted GO and KEGG enrichment analysis by DAVID 6...
Open Access Library J.   Vol.10, 2023
Doi:10.4236/oalib.1109747


Nov 30, 2022Open    Access

Distribution Estimation of Invasive Species Based on Crowdsourcing Reports

Yuxin Shi, Siyuan Liu, Tingzhen Liu
Species invasion will cause certain harm to the local ecosystem. Vespa mandarinia, discovered on Vancouver Island, is harmful to agriculture and predators of European honeybees. The government tried to use a crowdsourcing system to collect information and formulate policies to eliminate Vespa mandarinia. However, the information provided by the local population about Vespa mandarinia is not entirely accurate. For this problem, we build a method to mine trusted informat...
Open Access Library J.   Vol.9, 2022
Doi:10.4236/oalib.1109474


May 23, 2022Open    Access

A Bibliometric Analysis of the Research about Radical S-Adenosyl-Methionine Enzymes in 1999-2020

Pan Jiang, Huan Zhao, Lei Liu, Yuting Zhao, Ting Su, Yufan Yang, Xue Li
This paper aims to clarify the current research status and hot spots, as well as to predict future research trends about radical S-adenosyl-methionine (SAM) enzymes. We conducted this study based on 649 research papers about radical SAM enzymes published in the years of 1999 to 2020 on the Web of Science. Tools like CiteSpace were employed for statistical and visual network analysis of the time of publication, national cooperative relations, core authors, and co-word networks. Our findings inclu...
Open Access Library J.   Vol.9, 2022
Doi:10.4236/oalib.1108701


Sep 01, 2020Open    Access

A Consensus Mechanism Based on an Improved Genetic Algorithm

Chen Yang, Tao Wang, Kun Wang
An important feature of blockchain technology is that all participants jointly maintain transaction data and can achieve mutual trust relationships without integrated control, which relies on distributed consensus algorithms. Practical Byzantine Fault Tolerant algorithm (PBFT) is a fault-tolerant algorithm based on state machine replication, which solves the Byzantine error, that is, the malicious behavior of nodes. In PBFT, all participating nodes are divided into the primary node and backup no...
Open Access Library J.   Vol.7, 2020
Doi:10.4236/oalib.1106713


Jun 24, 2020Open    Access

Study on Patterns of Human Cancer Using SSN Method

Chaoyu Zhang
Human cancer, which has complex pathogenesis, is generally relative to the dysfunction of biological systems. Thus, our research is not at molecular level, but at system level, i.e. molecular network. In this paper, specially, we use PPI network. In order to construct a PPI network, we used the SSN method which is proposed by Professor X. Liu and others. The SSN method is distinct from the traditional network methods, especially in screening differential expressed genes. Besides, the traditional...
Open Access Library J.   Vol.7, 2020
Doi:10.4236/oalib.1106453


Mar 15, 2018Open    Access

Detection of Horizontal Transfer of Housekeeping and Hydrocarbons Catabolism Genes in Bacterial Genus with Potential to Application in Bioremediation Process

Edmo Montes Rodrigues, Fernanda de Souza Freitas, Tatiane de Paula Siqueira
In silico analysis can be useful to infer about the horizontal gene transfer (HGT) as well as to deduce about the evolutionary relations of catabolic genes. In this study, we performed the analysis of two housekeeping genes (fabD and rpoD) and two catabolic gene
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Open Access Library J.   Vol.5, 2018
Doi:10.4236/oalib.1104454


Mar 12, 2018Open    Access

Different Protocols of Physical Training: Effect on Markers of Oxidative Stress in Erythrocytes in Rats

Marcelo Costa-Junior, Wener Barbosa-Resende, Michel Barbosa de Araújo, Rodrigo Augusto Dalia, Leandro Pereira de Moura, Luciana Alves de Medeiros, Lucas Moreira Cunha, Eliete Luciano
The imbalance between oxidant molecules and antioxidant agents is characterized as oxidative stress (OS) and may lead to severe damage to the organism. In contrast, the physical training of aerobic and resistive character promotes increases of the antioxidant response, resulting in a balance and/or minimizing damage. Therefore, the objective of the study is to verify the effect of aerobic training, resistive training and concurren
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Open Access Library J.   Vol.5, 2018
Doi:10.4236/oalib.1104411


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