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Oct 10, 2024Open Access
Central alveolar hypoventilation (CAH) is a rare condition resulting from brainstem injury, characterised by a loss of automatic breathing. We present a case of a 16-year-old female initially diagnosed with a brainstem glioma based on magnetic resonance imaging brain. Following craniotomy and tumour debulking, she developed episodic apnoea during both wakefulness and sleep. Histopathological analysis of the brainstem specimen unexpectedly revealed a diagnosis of brainstem tuberculoma. Despite th...
Sep 30, 2024Open Access
Carbohydrate antigen 19-9 (CA 19-9) is a tumour-associated biomarker predominantly linked to pancreatic and colorectal cancers. Elevated serum levels of CA 19-9 in lung adenocarcinoma are rare, with few cases documented in the literature. Herein, we present two cases of metastatic lung adenocarcinoma with markedly elevated CA 19-9 levels, initially leading to a diagnostic suspicion of a pancreatic malignancy.
Sep 26, 2024Open Access
Spontaneous pneumomediastinum (SPM) is a rare complication of anti-melanoma differentiation-associated protein 5 (MDA5) positive clinically amyopathic dermatomyositis (CADM). Herein, we report an elderly patient presented with cutaneous signs and SPM. Serial workup confirmed the anti-MDA5 positive CADM. Treatment initially included methylprednisolone, cyclosporine, and cyclophosphamide, but recurrence led to the use of rituximab and mycophenolate mofetil, ultimately resolving the pneumomedi ...
Sep 05, 2024Open Access
Even though tyrosine kinase inhibitors (TKI) improve survival in non-small cell lung cancer (NSCLC), it is related to the risk of drug-induced pneumonitis. Whilst little is known regarding TKI-induced pneumonitis, adverse reactions carry a significant mortality rate and impact the available treatment options. Here, we present a case of an elderly gentleman diagnosed with metastatic ALK-positive NSCLC, who initially experienced ceritinib-induced skin vasculitis and subsequently developed acute re...
Sep 03, 2024Open Access
We present the case of a patient with advanced lung cancer who initially experienced breathlessness and right-sided chest pain. A chest X-ray revealed a large right-sided pneumothorax, for which a right-sided chest tube was inserted. Due to a persistent air leak, a right indwelling pleural catheter (IPC) was placed. One week later, the patient developed a left-sided pneumothorax. To reduce the length of hospital stay, a left IPC was inserted. However, two days after this intervention, the patien...
Sep 19, 2022Open Access
Introduction: Systemic lupus erythematosus (SLE) is the autoimmune disease with the highest prevalence of pulmonary involvement, which ranges from 20% to 90% of the patients, depending on the criteria employed in the cohorts being studied (symptomatology or histopathology). More than 50% of the patients develop pleuropulmonary manifestations at least once during the course of the disease; likewise, pleuropulmonary involvement has been associated with a higher rate of mortality. The purpose of th...
Sep 14, 2022Open Access
Tuberculosis (TB) remains a worldwide problem. Intestinal TB (ITB) is a serious public health problem in developing countries and has been associated with significant morbidity and mortality. TB is challenging due to the lack of specific clinical and laboratory features. At present, a combination of clinical, endoscopic, radiological, and pathological features continues to be the key to diagnosing ITB. The surgical forms, in particular perforation, are mainly due to the delayed diagnostic. We re...
May 24, 2022Open Access
Hemolysis of biological samples has long been considered to impact the results of conventional biochemical examinations for various reasons. For some years now, suppliers of biochemistry automats and reagents have been providing thresholds or indexes for hemolysis, icterus and lactescence beyond which the results are no longer reliable. Hemolysis can interfere with assays performed in the laboratory. These interferences are due to the release in serum or plasma of constituents present in red blo...
Jun 25, 2015Open Access
Background: Over the last years,
increasing attention has been focused on the prevalence of obstructive sleep
apnea (OSA) in idiopathic pulmonary fibrosis (IPF). Objective: To determine the
prevalence of OSA in a group of patients diagnosed with IPF. Materials and
Methods: Analytic retrospective study. Data were collected from the medical
records of all patients diagnosed with IPF who had polysomnography requested as
part of the study protocol in patients with interstitial lung diseases (ILD).
R...
May 18, 2015Open Access
Recently, along
with the development of biochemical and molecular immunological techniques, the
diagnosis methods have been improved in which preparing natural parasite
antigens, and genetically engineered recombinant antigens have been applied by using
agglutination test, complement fixation methods to detect the human’s serum
antibodies for parasite identification of paragonimus infections. To improve
the detection rate, some scholars have used phage peptide library technology to
further impro...
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