OALib 期刊
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Apr 19, 2018Open    AccessArticle

Wrinkle Severity Grading Scale: A Southeast Asia Study

Brian Tian
Objective wrinkle grading scales have been described for Caucasians and Japanese, but none for South-east Asians. Southeast Asians tend to be darker in skin complexion (usually skin types IV and above). A wrinkle scale using fairer Caucasian and Japanese skin, may not be easily applicable for the darker Southeast Asian skin. Therefore, in this paper, we describe and validate a wrinkle grading
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Apr 19, 2018Open    AccessArticle

Building Artificial Intelligence for Dermatological Practice

Brian Tian
Purpose: Wrinkles are the most visually obvious features of aging and are the prime target of a vast number of products (both medical and cosmetic). It is important for clinicians to be able to grade wrinkles objectively. Although wrinkles are easily recognisable for humans, it remains a very challenging task for computer vision systems to detect them automatically. In our center, we developed a wrinkle detection algorithm based o
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Jul 28, 2017Open    AccessArticle

The Role of Polypodium leucotomos Extract in the Treatment of Porphyria Cutanea Tarda

Michael Hatch, Lisa Mask-Bull, Michelle B. Tarbox
The dermatologic manifestations of porphyrias result from localized cutaneous formation of reactive oxygen species. The significance of these inflammatory mediators may extend beyond the skin, as increased oxidative stress may play a role in the systemic manifestations of porphyrias. Polypodium leucotomos is a tropical fern that has demonstrated antioxidant, ant
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Jul 27, 2016Open    AccessArticle

The Comparison of the Levels of Leukotriene B4, TGF-β1, Collagen in Keloid Fibroblasts and Normal Skin Fibroblast

Yuli Kurniawati, Oki Suwarsa, Achadiyani Agung, Sudigdo Adi
Keloid pathogenesis occurs due to the longer duration of inflammation and the increase in the production of several factors such as TGF-β1 that causes the increase of fibroblast proliferation and collagen synthesis. The role of B4 Leukotriene (LTB4) in keloid pathogenesis particularly in the inflammation phase and tissue proliferation has not been clearly elucid
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Oct 19, 2015Open    AccessArticle

The Effects of Life Line Facial Cream/Periobitum Serum and Micro-Needling of Photodamaged Skin: A Split-Face Randomized Study

Gordon H. Sasaki
Background: Human growth factors serve as secretomes that regulate skin cell proliferation/differentiation and production of extracellular elements of the matrix and treat photo-aging. Microneedling of skin can also improve aging skin by facilitating normal wound healing of the temporary dermal conduits for therapeutic and cosmetic benefits. Objectives: This open, randomized split-face and single-center controlled study evaluated the safety and efficacy of the application of a cosmeceutical form...


Apr 01, 2015Open    AccessArticle

Nosocomial Infections in a Morocco Burn Unit

Amine Rafik, Hakim Chabbak, Kawtare Jouhri, Mounia Diouri, Naima Bahechar, Abdes-samad Chlihi
Introduction: The bacterial nosocomial infection remains a common cause of death in patients who have sustained a severe burn injury. Material and Methods: We conducted a prospective study of 45 patients hospitalized in the ICU burns Hospital IBN-ROCHD of Casablanca over a period of six months, from 1 January 2014 to 30 June 2014. The criteria for nosocomial infection were those of the Center for Disease Control in Atlanta in 1988. Result: Incidence rates were calculated. The bacterial ecology o...


Oct 29, 2014Open    AccessArticle

Cutaneous Horn

Siddharth P. Dubhashi, Vivek D. Kulkarni, Adil Suleman, Ishant Rege, Harsh Kumar
A cutaneous horn (corn cutaneum) is a dense, hyperkeratotic conical projection of skin arising from an unusual cohesiveness of keratinized material. Cutaneous horns most frequently occur in sites that are exposed to actinic radiation or burns. Forearm, cartilaginous portion of the ear, legs, and hands may also be affected. Cutaneous horns can occur in sun protected areas. Histologic confirmation is necessary to rule out malignant changes. No clinical features reliably distinguish between benign ...


Aug 06, 2014Open    AccessArticle

Scalp Reconstruction Using Integra, an Alternative to Free Tissue Transfer—Case Report

Victoria Fung, Richard L. Chalmers, Jenny L. C. Geh
We present a case of scalp reconstruction using Integra® and split skin grafting after extensive excision of melanoma in a previously irradiated field. Radical resection of malignancy and application of Integra®, a dermal substitute, was performed. Following histological confirmation of complete excision, a split-thickness skin graft (SSG) was applied. After 14 months the patient remains fully healed and without recurrence. The 2-stage use of Integra®...


Jun 25, 2014Open    AccessArticle

Melanocytes and Melanoma Etiology

Miguel Angelo Rodrigues Brandao, Bruno de Oliveira Rocha, Juliana Dumêt Fernandes, Luiz Antonio Rodrigues de Freitas
Melanocytes are pigment-producing cells originated from the neural crest. Epidermal melanocytes contribute to photoprotection and thermoregulation by packaging melanin pigment intomelanosomes and sending them to keratinocytes. There are still many gaps in the understanding of early events of melanocyte differentiation and advanced melanoma regarding genetic and molecular processes. In this review, the authors present a summary of the main aspects of the melanocyte biology and its relation with t...


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