Background: Human growth factors serve as secretomes that regulate skin
cell proliferation/differentiation and production of extracellular elements
of the matrix and treat photo-aging. Microneedling of skin can also improve
aging skin by facilitating normal wound healing of the temporary dermal conduits for therapeutic and cosmetic
benefits. Objectives: This open, randomized split-face and single-center
controlled study evaluated the safety and efficacy of the application of a
cosmeceutical formulation, which incorporated growth factors derived from
cultured pluripotential stem cells of unfertilized human ovum, in the treatment
of photo-damaged facial skin. The use of micro-needling to stem cell-treated
skin was evaluated for additional benefit. Material and Methods: Ten subjects
in Group 1 with mild-to-moderate photo-damaged skin received the growth factor
emulsion to one side of the face and serum to the eyelids/periorbitum and
placebo on the contralateral side for twelve (12) weeks. Ten subjects in a
separate Group 2 with similar photo- damaged skin received the same growth factor
emulsions and serum to both sides of the face and eyelids/periorbitum, but only one side was treated with four
micro-needling procedures four weeks apart. Subjects in Group 1 were
assessed at baseline, 6 weeks and 12 weeks with the Canfield VISIA Investigator
System and standardized 2D photography. Subjects in Group 2 were similarly
assessed with the addition of the DermaLab Cortex System. Data analysis
compared the p-values with the alpha level for statistical difference. Results:
Group 1 subjects demonstrated a beneficial effect by VISIA Analysis on
reduction of pigmented spots, UV-light damage with more effective effacement of
wrinkles and textural changes after three months compared with that observed on
the placebo side. Group 2 subjects demonstrated more improvement by VISIA
Analysis in reduction of pigmentations,
UV-light damage, porphyrin spots, and wrinkles with more textural smoothness with
combined treatments than with cosmeceutical application alone. Cortex Analysis
of skin, receiving combined treatments, demonstrated marked improvements in
skin elasticity and hydration observed after cosmeceutical application alone.
Conclusions: The used growth factor-containing creams and serum have a
salutary effect on photodamaged skin whose effects may be further enhanced with
the addition of micro-needling without introduction of side-effects or complications.
Further investigations with a larger cohort of subjects for longer treatment
periods will be needed to confirm and extend these initial findings.
Cite this paper
Sasaki, G. H. (2015). The Effects of Life Line Facial Cream/Periobitum Serum and Micro-Needling of Photodamaged Skin: A Split-Face Randomized Study. Open Access Library Journal, 2, e1867. doi: http://dx.doi.org/10.4236/oalib.1101867.
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Permit Transdermal Delivery of Skin-Imper- meant Medications to Humans. Proceedings of the National Academy of
Sciences of the United States of America, 105, 2058-2063. http://dx.doi.org/10.1073/pnas.0710355105
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